Click here to close Hello! We notice that you are using Internet Explorer, which is not supported by Xenbase and may cause the site to display incorrectly. We suggest using a current version of Chrome, FireFox, or Safari.
Cell Dev Biol 2014 Feb 15;31:. doi: 10.4172/2168-9296.1000133.
Show Gene links Show Anatomy links

Embryonic Expression and Function of the Xenopus Ink4d Cyclin D-Dependent Kinase Inhibitor.

Doherty JR , Nilsson LM , Kuliyev E , Zhu H , Matthew R , Cleveland JL , Mead PE , Roussel MF .

Here we report the cloning and functional characterization of the cyclin D-dependent kinase 4 and 6 (Cdk4/6) inhibitory protein Cdkn2d/p19Ink4d of Xenopuslaevis (Xl-Ink4d). Xl-Ink4d is the only Ink4 family gene highly expressed during Xenopus development and its transcripts were detected maternally and during neurulation. The Xl-Ink4d protein has 63% identity to mouse and human Cdkn2d/p19Ink4d and its function as a negative regulator of cell cycle traverse is evolutionary conserved. Indeed, Xl-lnk4d can functionally substitute for mouse Cdkn2d in binding to mouse Cdk4 and inhibiting cyclin-D1-dependent CDK4 kinase activity. Further, enforced expression of Xl-lnk4d arrests mouse fibroblasts in the G1 phase of the cell cycle. These findings indicate that CDKN2d/p19Ink4d is conserved through vertebrate evolution and suggest Xl-lnk4d may contribute to the development of Xenopuslaevis.

PubMed ID: 25309971
PMC ID: PMC4192657
Article link: Cell Dev Biol
Grant support: [+]

Species referenced: Xenopus
Genes referenced: ank1 ccnd1 cdk4 cdk6 cdkn2d odc1
Antibodies: Cdkn2d Ab1

Article Images: [+] show captions
References [+] :
Chen, Progressive hearing loss in mice lacking the cyclin-dependent kinase inhibitor Ink4d. 2003, Pubmed