Click here to close Hello! We notice that you are using Internet Explorer, which is not supported by Xenbase and may cause the site to display incorrectly. We suggest using a current version of Chrome, FireFox, or Safari.
Biotechnol Bioeng 2013 Jul 01;1107:1811-21. doi: 10.1002/bit.24890.
Show Gene links Show Anatomy links

Transcription activator-like effector nucleases (TALENs): a highly efficient and versatile tool for genome editing.

Sun N , Zhao H .

Transcription activator-like effector (TALE) nucleases (TALENs) have recently emerged as a revolutionary genome editing tool in many different organisms and cell types. The site-specific chromosomal double-strand breaks introduced by TALENs significantly increase the efficiency of genomic modification. The modular nature of the TALE central repeat domains enables researchers to tailor DNA recognition specificity with ease and target essentially any desired DNA sequence. Here, we comprehensively review the development of TALEN technology in terms of scaffold optimization, DNA recognition, and repeat array assembly. In addition, we provide some perspectives on the future development of this technology.

PubMed ID: 23508559
Article link: Biotechnol Bioeng
Grant support: [+]