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Mech Dev 2014 Feb 01;131:57-67. doi: 10.1016/j.mod.2013.10.003.
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The ETS transcription factor Etv1 mediates FGF signaling to initiate proneural gene expression during Xenopus laevis retinal development.

Fibroblast growth factor signaling plays a significant role in the developing eye, regulating both patterning and neurogenesis. Members of the Pea3/Etv4-subfamily of ETS-domain transcription factors (Etv1, Etv4, and Etv5) are transcriptional activators that are downstream targets of FGF/MAPK signaling, but whether they are required for eye development is unknown. We show that in the developing Xenopus laevis retina, etv1 is transiently expressed at the onset of retinal neurogenesis. We found that etv1 is not required for eye specification, but is required for the expression of atonal-related proneural bHLH transcription factors, and is also required for retinal neuron differentiation. Using transgenic reporters we show that the distal atoh7 enhancer, which is required for the initiation of atoh7 expression in the Xenopus retina, is responsive to both FGF signaling and etv1 expression. Thus, we conclude that Etv1 acts downstream of FGF signaling to regulate the initiation of neurogenesis in the Xenopus retina.

PubMed ID: 24219979
PMC ID: PMC3959783
Article link: Mech Dev
Grant support: [+]

Species referenced: Xenopus laevis
Genes referenced: ascl3 atoh7 etv1 etv4 fzd5 mapk1 neurod1 neurog1 neurog2 pax6 rax sox2
Morpholinos: etv1 MO1 fzd5 MO1

Article Images: [+] show captions
References [+] :
Agathocleous, A directional Wnt/beta-catenin-Sox2-proneural pathway regulates the transition from proliferation to differentiation in the Xenopus retina. 2009, Pubmed, Xenbase