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Sci Rep 2013 Jan 01;3:1552. doi: 10.1038/srep01552.
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Global hyper-synchronous spontaneous activity in the developing optic tectum.

Imaizumi K , Shih JY , Farris HE .

Studies of patterned spontaneous activity can elucidate how the organization of neural circuits emerges. Using in vivo two-photon Ca(2+) imaging, we studied spatio-temporal patterns of spontaneous activity in the optic tectum of Xenopus tadpoles. We found rhythmic patterns of global synchronous spontaneous activity between neurons, which depends on visual experience and developmental stage. By contrast, synchronous spontaneous activity between non-neuronal cells is mediated more locally. To understand the source of the neuronal spontaneous activity, input to the tectum was systematically removed. Whereas removing input from the visual or mechanosensory system alone had little effect on patterned spontaneous activity, removing input from both systems drastically altered it. These results suggest that either input is sufficient to maintain the intrinsically generated spontaneous activity and that patterned spontaneous activity results from input from multisensory systems. Thus, the amphibian midbrain differs from the mammalian visual system, whose spontaneous activity is controlled by retinal waves.

PubMed ID: 23531884
PMC ID: PMC3609019
Article link: Sci Rep
Grant support: [+]

Species referenced: Xenopus laevis
Genes referenced: ctrl mcc tecta.2

Article Images: [+] show captions
References [+] :
Ackman, Retinal waves coordinate patterned activity throughout the developing visual system. 2012, Pubmed