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Dev Growth Differ 2012 Sep 01;547:702-16. doi: 10.1111/j.1440-169X.2012.01371.x.
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Pou-V factor Oct25 regulates early morphogenesis in Xenopus laevis.

Julier A , Goll C , Korte B , Knöchel W , Wacker SA .

POU-V class proteins like Oct4 are crucial for keeping cells in an undifferentiated state. An Oct4 homologue in Xenopus laevis, Oct25, peaks in expression during early gastrulation, when many cells are still uncommitted. Nevertheless, extensive morphogenesis is taking place in all germ layers at that time. Phenotypical analysis of embryos with Oct25 overexpression revealed morphogenesis defects, beginning during early gastrulation and resulting in spina-bifida-like axial defects. Analysis of marker genes and different morphogenesis assays show inhibitory effects on convergence and extension and on mesoderm internalization. On a cellular level, cell-cell adhesion is reduced. On a molecular level, Oct25 overexpression activates expression of PAPC, a functional inhibitor of the cell adhesion molecule EP/C-cadherin. Intriguingly, Oct25 effects on cell-cell adhesion can be restored by overexpression of EP/C-cadherin or by inhibition of the PAPC function. Thus, Oct25 affects morphogenesis via activation of PAPC expression and subsequent functional inhibition of EP/C-cadherin.

PubMed ID: 22957893
Article link: Dev Growth Differ

Species referenced: Xenopus laevis
Genes referenced: acss2.2 chrd.1 krt12.4 mal myod1 pcdh1 pcdh8 pcdh8.2 pou5f3 pou5f3.2 snai1 sox17a sox2 sox3 tbxt
Morpholinos: pou5f3.2 MO2

Phenotypes: Xla Wt + pou5f3.2 (fig.1. f) [+]

Article Images: [+] show captions