Click here to close Hello! We notice that you are using Internet Explorer, which is not supported by Xenbase and may cause the site to display incorrectly. We suggest using a current version of Chrome, FireFox, or Safari.
Int J Dev Biol 2011 Jan 01;5510-12:923-31. doi: 10.1387/ijdb.103253in.
Show Gene links Show Anatomy links

The RNA-binding protein Xp54nrb isolated from a Ca²+-dependent screen is expressed in neural structures during Xenopus laevis development.

Neant I , Deisig N , Scerbo P , Leclerc C , Moreau M .

In amphibian embryos, calcium (Ca(2+)) signalling is a necessary and sufficient event to induce neural fate. Transient elevations of [Ca(2+)]i are recorded in neural tissue precursor cells in whole embryos during gastrulation. Using a subtractive cDNA library between control ectoderm (animal caps) and ectoderm induced toward a neural fate by Ca(2+) release, we have isolated several Ca(2+)-induced target genes. Among the isolated genes, Xp54nrb encodes a protein which exhibits the RRM domains characteristic of RNA binding proteins, and is implicated in pre-mRNA splicing steps. Here we show that the Xp54nrb transcripts are expressed throughout early developmental stages, specifically in the neural and sensorial territories and that Xp54nrb could be involved in anterior neural patterning.

PubMed ID: 22252489
Article link: Int J Dev Biol

Species referenced: Xenopus laevis
Genes referenced: gal.2 nono pax3 pou3f4 rpe snai2 sox2 tbxt zic3
Morpholinos: nono MO1

Article Images: [+] show captions