Click here to close Hello! We notice that you are using Internet Explorer, which is not supported by Xenbase and may cause the site to display incorrectly. We suggest using a current version of Chrome, FireFox, or Safari.
Zygote 2013 Feb 01;211:1-9. doi: 10.1017/S0967199411000207.
Show Gene links Show Anatomy links

Involvement of cAMP and calmodulin in endocytic yolk uptake during Xenopus laevis oogenesis.

Luque ME , Serrano Mde L , Mónaco ME , Villecco EI , Sánchez SS .

The aim of the present study was to show the participation and physiological role of calmodulin (CaM) and cAMP during vitellogenin endocytic uptake in the amphibian Xenopus laevis. The results showed a differential distribution of CaM in the ovary follicles during oogenesis. The CaM intracellular localization was not affected by gap junction's downregulation and CaM inhibition did not completely abolished the endocytic activity of oocytes. We showed that cAMP was able to completely rescue the endocytic competence in follicles in which gap junctional communication had been disrupted by octanol. Moreover cAMP was capable of restoring oocyte endocytic capability in the presence of octanol and stelazine, a CaM inhibitor. We propose that, in Vtg uptake regulation, cAMP is upstream of CaM during the endocytic signalling pathway.

PubMed ID: 21554771
Article link: Zygote

Species referenced: Xenopus laevis
Genes referenced: calm1