Neilson KM , Pignoni F , Yan B , Moody SA .

R01 EY1316709 NEI NIH HHS , R03 HD055321 NICHD NIH HHS , R01 EY013167-09 NEI NIH HHS , R03 HD055321-01A1 NICHD NIH HHS , R01 EY013167 NEI NIH HHS

             face development

           OTOFACIOCERVICAL SYNDROME 1; OTFCS
           BRANCHIOOTIC SYNDROME 3; BOS3

	Figure 2. Expression of Eya genes. A,B: Eya1 is diffusely expressed throughout the ectoderm (ecto) of the animal (an) cap of the blastula (A) and the gastrula (B; side views). veg, vegetal pole; bl, blastopore lip; endo, endoderm. C–E: Eya3 is detected in the animal blastomeres of the 32-cell embryo (C), the animal cap of the blastula (D), and enhanced in the dorsal ectoderm of the late gastrula (E; side views). F: At neural plate stages, Eya3 is expressed throughout the neural plate (np) and preplacodal ectoderm (PPE), but not the cement gland (cg; anterolateral view). G–O: Eya2 expression. G: Eya2 is diffusely expressed throughout the neural plate and PPE (Anterior view). H: Upon neural tube closure, Eya2 is expressed in the adeno-hypophyseal (AH), olfactory (olf), trigeminal (Vp), and dorsolateral (dlp) placodes. I: It also is detected in the caudal neural tube (nt) and somites (so) (H, anterior view; I, dorsal view). J–L: At tail bud (J) and larval (K,L) stages, Eya2 is strongly expressed in the olfactory (olf), otic (oto), and various other placodes (pl) and their cranial ganglion derivatives (crg). Note that the lens placode (L) does not express Eya2. There is additional expression in the nephric mesoderm (ne) and hypaxial muscle precursors (hyp; J, K, side views; L, anterior view). M–O: In transverse sections at the levels of the diencephalon (M), otocyst (N), and caudal hindbrain (O), Eya2 expression is notable in the cranial ganglia (profundal, Pg; maxillo-mandibular branch of the trigeminal, Vg; VIIIg, IXg), otocyst, and somitic and nephric mesoderm.
	Figure 3. Expression of Groucho-related genes (Grg). A: stage VI oocyte with Grg4 transcripts enhanced on animal (an) side (side view). B: An eight-cell embryo with maternal ESG1 transcripts enhanced in the animal blastomeres (side view). C: In the blastula, animal cap ectoderm expresses Grg5 (side view). D: In the gastrula, the entire ectoderm expresses Grg4, whereas the preinvoluted mesoderm (meso) and endoderm do not (side view). E–G: At neural plate stages, Grg4 (E), ESG1 (F), and Grg5 (G) are expressed in the neural plate and preplacodal ectoderm (PPE); Grg5 is also expressed in the cement gland (anterior views). H: ESG1 is expressed throughout the neural tube, but most strongly in the anterior part (ant. nt). It is also detected in the neural crest (nc), dorsal epidermis (epi), and somites (dorsal view). I: At tail bud stages, ESG1 expression is strong in the entire neural tube, migrating neural crest, somites, otocyst, and tail bud (tb; side view). J: At tail bud stages, Grg4 is weakly detected in the cement gland (ventral view). K: At larval stages, Grg4 is expressed throughout the brain (b), retina (r), placode derivatives (crg, L, olf, oto), and the branchial arches (BA; side view). L: ESG1 is expressed in the same tissues, and also is detected in the heart (h), ventral gut (vg), nephric mesoderm and the initial outgrowth of the lateral line (LL; side view). M–R: In transverse sections at the levels of the anterior trunk (M), forebrain (N–P) and hindbrain (Q,R), expression of the various Grg-related genes is noted in the nephric mesoderm, forebrain (fb), hindbrain (hb), retina, branchial arches, cement gland, various placodes (olf, oto, IXg, epibranchial [ebp]) and heart.
	Figure 4. Expression of a CG17265-related gene, Xt-ccd85c. A: Diffuse expression of Xt-ccd85c throughout the anterior neural plate and PPE (anterior view). B: At neural tube closure, there is diffuse expression throughout the neural tube, retina, dorsal epidermis, otocyst, and branchial arches (side view). C: At late tail bud stages, the pineal (p), retina, midbrain, and hindbrain are stained. There also is weak staining in the lens, otocyst, and branchial arches (side view). D: Dorsal view at larval stage showing expression extending into the forebrain. E–G: Transverse sections at forebrain (E), hindbrain (F), and caudal hindbrain (G) demonstrate restricted neural expression.
	Figure 5. Expression of SOBP-related genes. A: zfp198 mRNA is concentrated in the animal blastomeres at the eight-cell stage (side view). B: zfp198 is expressed throughout the ectoderm of the gastrula (side view). C: At early neural plate, LOC414497 is expressed throughout the neural plate, preplacodal ectoderm (PPE), and dorsal epidermis (anterolateral view). D: At neural tube closure, neural crest and lens placode (Lp) expression of zfp198 becomes apparent (anterolateral view). E–G: At late tail bud, zfp198 (E) and LOC414497 (F) are expressed throughout the brain, retina, placode derivatives (olf, L, crg, oto) and branchial arches, whereas Xt-Sobp (G) is expressed in patches in the brain and in several placode derivatives (olf, crg, oto; side view). H: At larval stages, Xt-Sobp expression extends into the forebrain (side view). I–K: Transverse sections at forebrain (I), hindbrain (J), and spinal (K) levels demonstrate expression of zfg198 and LOC414497 in neural (fb, r, hb, sc), branchial arch, otocyst and somites. L: Transverse section at hindbrain demonstrates Xt-Sobp more restricted expression in lateral hindbrain, otocyst, and cranial ganglia.
	Figure 6. Expression of a CG1135-related gene. A: LOC100049093 is expressed diffusely through the neural plate, preplacodal ectoderm (PPE), and dorsal epidermis (epi; anterior view). B: At neural tube closure, it is slightly enhanced in the neural tube, PPE, and neural crest (anterior view). C: At larval stages, it is detected in the brain, retina, several placode derivatives (L, olf, oto, crg), branchial arches, and nephric mesoderm (side view). D–F: Transverse sections at forebrain (D), hindbrain (E), and spinal (F) levels demonstrate extensive neural (fb, r, hb, sc), placodal (L, oto, IXg), and branchial arch, and weak expression in the nephric mesoderm.
	Figure 7. Expression of a CG7878-related gene. A: Ddx43 is diffusely expressed throughout the neural plate, preplacodal ectoderm (PPE), and dorsal epidermis (anterior view). B: At neural tube closure, it is very weakly expressed in the neural tube, a few placodes (dlp, L) and migrating neural crest (side view). C: At larval stages, it is expressed throughout the brain, retina, several placode derivatives (olf, oto, L), branchial arches, somites, heart, and nephric mesoderm (side view). D–F: Transverse sections at midbrain (D), hindbrain (E), and spinal (F) levels demonstrate neural (mb, r, hb, sc), lens, branchial arch, heart, otocyst, somite, and nephric mesoderm expression.
	Figure 8. Expression of a CKIIβ-related gene. A: CKIIβ is expressed throughout the ectoderm of the gastrula (dorsal view). B: At neural plate stages, epidermal staining continues, but expression is enhanced in the neural plate and preplacodal ectoderm (PPE; anterolateral view). C: At neural tube closure, CKIIβ is expressed throughout the neural tube, in placodes (AH, olf, L) and neural crest (anterior view). D: At tail bud stages, brain, retina, placodal structures (olf, L, crg, oto), and branchial arches are stained (side view). E: At larval stages, the nephric mesoderm is additionally stained (side view). Transverse sections at hindbrain (F) and spinal (G) levels demonstrate neural (hb, sc), branchial arch, otocyst, cranial ganglion (IXg), somite, and nephric mesoderm expression.
	Figure 9. Expression of a CG10576-related gene. A: At late gastrula stages, the ectodermal expression of 2G4 is enhanced on the dorsal side (d. ecto; v. ecto, ventral ectoderm; side view). B: At neural plate stages, 2G4 is expressed diffusely throughout the neural plate, preplacodal ectoderm (PPE), and dorsal epidermis (anterolateral view). C: 2G4 is expressed throughout the neural tube, retina, PPE, cranial neural crest, and epidermis (anterior view). D: At tail bud stages, 2G4 is intensely expressed in the retina, diencephalon (di), hindbrain, placodes (olf, L, oto), branchial arches, and weakly in the nephric mesoderm (side view). E: At larval stages, the neural tube expression expands to the dorsal spinal cord, and nephric mesoderm staining is prominent (side view). F,G: Transverse sections at hindbrain (F) and spinal (G) levels demonstrate neural (hb, sc), branchial arch, otocyst, epidermal and nephric mesoderm expression.
	Fig. 10. Expression of CG5033-related genes. A: MGC68939 mRNA is detected in animal blastomeres of the 16-cell embryo (side view). B: It is expressed throughout the ectoderm of the gastrula, but not in the endoderm (side view). C: Bop-1 is expressed throughout the neural plate, preplacodal ectoderm (PPE), and dorsal epidermis; anterolateral view). D: MGC68939 is expressed in the anterior neural tube, cranial neural crest, PPE, and some placodes (e.g., olf; anterolateral view). E: At early tail bud, MGC68939 is expressed in placodes (L, oto), the migrating neural crest, somites and tail bud (side view). F: At late tail bud, Bop-1 is expressed in the brain, retina, placodes (L, oto), branchial arches, somites, nephric mesoderm, tail bud, and ventral gut (side view). G: At late tail bud stages, MGC68939 staining is very similar to that of Bop-1, ventral gut staining is not detected until larval stages (side view). H: Transverse sections at forebrain (H), hindbrain (I), rostral spinal (J), and more caudal spinal (K) levels demonstrate neural (fb, r, hb, sc), branchial arch, lens, otocyst, somite, nephric mesoderm, and ventral gut expression.
	Fig. 11. Expression of Gadd45-related genes. A: Weak expression of Gadd45g in the animal cap ectoderm of the blastula (side view). B: Gadd45a is diffusely expressed in the ectoderm and noninvoluted mesoderm of the gastrula (side view). C,D: Gadd45a is expressed throughout the neural plate, PPE and cement gland (C, anterior view; D, dorsal view). E,F: At neural tube closure, Gadd45a expression in the anterior part of the embryo (E) is enhanced in the cement gland and pineal, and in the posterior part (F) in a patch of paraxial mesoderm (pm) and in mesoderm surrounding the cloaca (arrowhead). G: At neural tube stages, Gadd45g is expressed in the neural tube, including pineal, and multiple placodes (olf, L, Vp, dlp; anterior view). H: At neural plate, Gadd45g is expressed in stripes of primary neurons (pn) and the trigeminal placode (Vp; dorsal view). I: At larval stages, Gadd45a expression becomes weak and diffuse throughout the head and anterior trunk, and is lost from the cement gland (side view). J: At larval stages, Gadd45g expression is confined to the brain, retina, anterior spinal cord, and placode derivatives (olf, L, crg, oto, ebp; side view). K,L,M: Transverse sections at forebrain (L), hindbrain (M), rostral spinal (K) levels demonstrate neural (fb, r, hb, sc) and placodal (L, oto, crg, ebp) expression.
	tle4 (transducin-like enhancer of split 4 (E(sp1) homolog)) gene expression in Xenopus tropicalis embryos, NF stage 28, assayed by in situ hybridization, head and upper trunk region, lateral view, anterior left, dorsal up.
	bop1 (BOP1 ribosomal biogenesis factor) gene expression in Xenopus tropicalis embryos, NF stage 28, as assayed by in situ hybridization, lateral view, anterior left, dorsal up.
	bop1 (BOP1 ribosomal biogenesis factor) gene expression in Xenopus tropicalis embryos, NF stage 15, as assayed by in situ hybridization, anterodorsal-lateral view, anterior left, dorsal up.
	ccdc85c (coiled-coil domain containing 85C) gene expression in Xenopus tropicalis embryo, assayed via in situ hybridization, NF stage 18, anterior view, dorsal up.
	ccdc85c (coiled-coil domain containing 85C ) gene expression in Xenopus tropicalis embryo, assayed via in situ hybridization, NF stage 28, lateral view, head and trunk region, anterior left, dorsal up.
	zmym2 (zinc finger, MYM-type 2) gene expression in Xenopus tropicalis embryo, assayed via in situ hybridization, NF stage 5 (16 cell), lateral view, animal pole up.
	zmym2 (zinc finger, MYM-type 2) gene expression in Xenopus tropicalis embryo, assayed via in situ hybridization, NF stage 20/21, anterior-lateral view, dorsal up.
	mcrs1 (microspherule protein 1) gene expression in Xenopus tropicalis embryo, assayed via in situ hybridization, A: NF stage 17/18, dorsal view, anterior right. B: NF stage 20/21, anterior view dorsal up.
	mcrs1 (microspherule protein 1) gene expression in Xenopus tropicalis embryo, assayed via in situ hybridization, NF stage , lateral view, anterior left, dorsal up.
	mcrs1 (microspherule protein 1) gene expression in Xenopus tropicalis embryo, assayed via in situ hybridization, NF stage 28, transverse section through head region view, dorsal up.
	ddx43 (DEAD (Asp-Glu-Ala-Asp) box polypeptide 43) gene expression in Xenopus tropicalis embryo, assayed via in situ hybridization, NF stage 17/18, anterior view, dorsal up.
	ddx43 (DEAD (Asp-Glu-Ala-Asp) box polypeptide 43) gene expression in Xenopus tropicalis embryo, assayed via in situ hybridization, NF stage 20/21, anterior- lateral view, dorsal up.
	ddx43 (DEAD (Asp-Glu-Ala-Asp) box polypeptide 43) gene expression in Xenopus tropicalis embryo, assayed via in situ hybridization, NF stage 28, lateral view, anterior left, dorsal up.
	csnk2b (casein kinase 2, beta polypeptide) gene expression in Xenopus tropicalis embryo, assayed via in situ hybridization, NF stage 9/10, lateral view, anterior left, dorsal up.
	csnk2b (casein kinase 2, beta polypeptide) gene expression in Xenopus tropicalis embryo, assayed via in situ hybridization, NF stage 20/21, lateral view, anterior left, dorsal up.
	csnk2b (casein kinase 2, beta polypeptide) gene expression in Xenopus tropicalis embryo, assayed via in situ hybridization, NF stage 28, lateral view, anterior left, dorsal up.
	pa2g4 (proliferation-associated 2G4, 38kDa) gene expression in Xenopus tropicalis embryo, assayed via in situ hybridization, NF stage 17/18, anterior-lateral view, dorsal up.
	pa2g4 (proliferation-associated 2G4, 38kDa) gene expression in Xenopus tropicalis embryo, assayed via in situ hybridization, NF stage , lateral view, anterior left, dorsal up.
	eya2 (EYA transcriptional coactivator and phosphatase 2 ) gene expression in X. laevis embryo, assayed via in situ hybridization, NF stage 17, anterior view, dorsal up.
	eya2 (EYA transcriptional coactivator and phosphatase 2 ) gene expression in X. laevis embryo, assayed via in situ hybridization.
	eya2 (EYA transcriptional coactivator and phosphatase 2 ) gene expression in X. laevis embryo, assayed via in situ hybridization, NF stage 20, dorsal view, anterior left.
	eya2 (EYA transcriptional coactivator and phosphatase 2 ) gene expression in X. laevis embryo, assayed via in situ hybridization, NF stage 24, lateral view of head region, anterior left, dorsal up. key: pl: cranial placodes, ne: pronephric mesenchyme, oto: otic vesicle, olf: olfactory placode. L: lens placode with no expression.
	eya2 (EYA transcriptional coactivator and phosphatase 2 ) gene expression in X. laevis embryo, assayed via in situ hybridization, NF stage 28, lateral view of head and trunk region, anterior left, dorsal up.

Abdelhak, A human homologue of the Drosophila eyes absent gene underlies branchio-oto-renal (BOR) syndrome and identifies a novel gene family. 1997, Pubmed

Abdelhak, A human homologue of the Drosophila eyes absent gene underlies branchio-oto-renal (BOR) syndrome and identifies a novel gene family. 1997, Pubmed
Abe, EYA4, deleted in a case with middle interhemispheric variant of holoprosencephaly, interacts with SIX3 both physically and functionally. 2009, Pubmed
Bai, Eyes absent, a key repressor of polar cell fate during Drosophila oogenesis. 2002, Pubmed
Baker, Vertebrate cranial placodes I. Embryonic induction. 2001, Pubmed , Xenbase
Bernard, A new recurrent and specific cryptic translocation, t(5;14)(q35;q32), is associated with expression of the Hox11L2 gene in T acute lymphoblastic leukemia. 2001, Pubmed
Bidet, Modifiers of muscle and heart cell fate specification identified by gain-of-function screen in Drosophila. 2003, Pubmed
Bonini, The eyes absent gene: genetic control of cell survival and differentiation in the developing Drosophila eye. 1993, Pubmed , Xenbase
Bonini, The Drosophila eyes absent gene directs ectopic eye formation in a pathway conserved between flies and vertebrates. 1997, Pubmed
Bonini, Multiple roles of the eyes absent gene in Drosophila. 1998, Pubmed
Brugmann, Six1 promotes a placodal fate within the lateral neurogenic ectoderm by functioning as both a transcriptional activator and repressor. 2004, Pubmed , Xenbase
Brugmann, Induction and specification of the vertebrate ectodermal placodes: precursors of the cranial sensory organs. 2005, Pubmed , Xenbase
Buchou, Disruption of the regulatory beta subunit of protein kinase CK2 in mice leads to a cell-autonomous defect and early embryonic lethality. 2003, Pubmed
Burks, FGF signalling modulates transcriptional repression by Xenopus groucho-related-4. 2009, Pubmed , Xenbase
Carpenter, Identification of a novel 81-kDa component of the Xenopus origin recognition complex. 1998, Pubmed , Xenbase
Chen, Jxc1/Sobp, encoding a nuclear zinc finger protein, is critical for cochlear growth, cell fate, and patterning of the organ of corti. 2008, Pubmed
Cheyette, The Drosophila sine oculis locus encodes a homeodomain-containing protein required for the development of the entire visual system. 1994, Pubmed
Chiao, High-throughput functional screen of mouse gastrula cDNA libraries reveals new components of endoderm and mesoderm specification. 2005, Pubmed , Xenbase
Choudhury, Cloning and developmental expression of Xenopus cDNAs encoding the Enhancer of split groucho and related proteins. 1997, Pubmed , Xenbase
Christophorou, Activation of Six1 target genes is required for sensory placode formation. 2009, Pubmed
Courey, Transcriptional repression: the long and the short of it. 2001, Pubmed
David, Xenopus Eya1 demarcates all neurogenic placodes as well as migrating hypaxial muscle precursors. 2001, Pubmed , Xenbase
Davidovic, The nuclear microspherule protein 58 is a novel RNA-binding protein that interacts with fragile X mental retardation protein in polyribosomal mRNPs from neurons. 2006, Pubmed
Dear, The Hox11 gene is essential for cell survival during spleen development. 1995, Pubmed
Dehni, TLE expression correlates with mouse embryonic segmentation, neurogenesis, and epithelial determination. 1995, Pubmed
Depreux, Eya4-deficient mice are a model for heritable otitis media. 2008, Pubmed
Dominguez, Protein kinase CK2 is required for dorsal axis formation in Xenopus embryos. 2004, Pubmed , Xenbase
Dorner, A genomewide screen for components of the RNAi pathway in Drosophila cultured cells. 2006, Pubmed
Esteve, cSix4, a member of the six gene family of transcription factors, is expressed during placode and somite development. 1999, Pubmed
Fabrizio, A somatic role for eyes absent (eya) and sine oculis (so) in Drosophila spermatocyte development. 2003, Pubmed
Ferrando, Gene expression signatures define novel oncogenic pathways in T cell acute lymphoblastic leukemia. 2002, Pubmed
Fogelgren, Misexpression of Six2 is associated with heritable frontonasal dysplasia and renal hypoplasia in 3H1 Br mice. 2008, Pubmed
Fogelgren, Deficiency in Six2 during prenatal development is associated with reduced nephron number, chronic renal failure, and hypertension in Br/+ adult mice. 2009, Pubmed
Ghanbari, Molecular cloning and embryonic expression of Xenopus Six homeobox genes. 2001, Pubmed , Xenbase
Giot, A protein interaction map of Drosophila melanogaster. 2003, Pubmed
Grifone, Eya1 and Eya2 proteins are required for hypaxial somitic myogenesis in the mouse embryo. 2007, Pubmed
Guerra, Protein kinase CK2 and its role in cellular proliferation, development and pathology. 1999, Pubmed
Hatano, Deregulation of a homeobox gene, HOX11, by the t(10;14) in T cell leukemia. 1991, Pubmed
Hatano, A novel pathogenesis of megacolon in Ncx/Hox11L.1 deficient mice. 1997, Pubmed
Heanue, Synergistic regulation of vertebrate muscle development by Dach2, Eya2, and Six1, homologs of genes required for Drosophila eye formation. 1999, Pubmed
Hirohashi, p78/MCRS1 forms a complex with centrosomal protein Nde1 and is essential for cell viability. 2006, Pubmed
Hollander, Genomic instability in Gadd45a-deficient mice. 1999, Pubmed
Hoskins, Transcription factor SIX5 is mutated in patients with branchio-oto-renal syndrome. 2007, Pubmed
Ijiri, A novel role for GADD45beta as a mediator of MMP-13 gene expression during chondrocyte terminal differentiation. 2005, Pubmed
Ikeda, Molecular interaction and synergistic activation of a promoter by Six, Eya, and Dach proteins mediated through CREB binding protein. 2002, Pubmed
Ishihara, Differential expression of Eya1 and Eya2 during chick early embryonic development. 2008, Pubmed , Xenbase
Johnson, Inner ear and kidney anomalies caused by IAP insertion in an intron of the Eya1 gene in a mouse model of BOR syndrome. 1999, Pubmed
Kawahara, Zebrafish GADD45beta genes are involved in somite segmentation. 2005, Pubmed
Kawakami, Structure, function and expression of a murine homeobox protein AREC3, a homologue of Drosophila sine oculis gene product, and implication in development. 1996, Pubmed
Kawakami, Six family genes--structure and function as transcription factors and their roles in development. 2000, Pubmed
Kenyon, Fly SIX-type homeodomain proteins Sine oculis and Optix partner with different cofactors during eye development. 2005, Pubmed
Killian, Contribution of the BOP1 gene, located on 8q24, to colorectal tumorigenesis. 2006, Pubmed
Kobayashi, Expression of three zebrafish Six4 genes in the cranial sensory placodes and the developing somites. 2000, Pubmed
Kobayashi, The homeobox protein Six3 interacts with the Groucho corepressor and acts as a transcriptional repressor in eye and forebrain formation. 2001, Pubmed
Koop, Transcripts of Grg4, a murine groucho-related gene, are detected in adjacent tissues to other murine neurogenic gene homologues during embryonic development. 1996, Pubmed
Kowalinski, The crystal structure of Ebp1 reveals a methionine aminopeptidase fold as binding platform for multiple interactions. 2007, Pubmed
Kriebel, Xeya3 regulates survival and proliferation of neural progenitor cells within the anterior neural plate of Xenopus embryos. 2007, Pubmed , Xenbase
Kumar, Branchio-oto-renal syndrome: identification of novel mutations, molecular characterization, mutation distribution, and prospects for genetic testing. , Pubmed
Laclef, Thymus, kidney and craniofacial abnormalities in Six 1 deficient mice. 2003, Pubmed
Larkin, Clustal W and Clustal X version 2.0. 2007, Pubmed
Leon, Grg3, a murine Groucho-related gene, is expressed in the developing nervous system and in mesenchyme-induced epithelial structures. 1997, Pubmed
Li, Eya protein phosphatase activity regulates Six1-Dach-Eya transcriptional effects in mammalian organogenesis. 2003, Pubmed
Lieberman, CK2 beta, which inhibits Mos function, binds to a discrete domain in the N-terminus of Mos. 2004, Pubmed , Xenbase
Lin, Essential role of the 58-kDa microspherule protein in the modulation of Daxx-dependent transcriptional repression as revealed by nucleolar sequestration. 2002, Pubmed
Liu, A systematic analysis of Tinman function reveals Eya and JAK-STAT signaling as essential regulators of muscle development. 2009, Pubmed
Logan, Tlx-1 and Tlx-3 homeobox gene expression in cranial sensory ganglia and hindbrain of the chick embryo: markers of patterned connectivity. 1998, Pubmed
Lu, The tcl-3 proto-oncogene altered by chromosomal translocation in T-cell leukemia codes for a homeobox protein. 1991, Pubmed
Lu, GADD45gamma mediates the activation of the p38 and JNK MAP kinase pathways and cytokine production in effector TH1 cells. 2001, Pubmed
López-Ríos, Six3 and Six6 activity is modulated by members of the groucho family. 2003, Pubmed , Xenbase
Ma, Neuronal activity-induced Gadd45b promotes epigenetic DNA demethylation and adult neurogenesis. 2009, Pubmed
Martelange, Identification on a human sarcoma of two new genes with tumor-specific expression. 2000, Pubmed
Mathieu, HAGE, a cancer/testis antigen expressed at the protein level in a variety of cancers. 2010, Pubmed
Miyasaka, Molecular cloning and expression of mouse and human cDNA encoding AES and ESG proteins with strong similarity to Drosophila enhancer of split groucho protein. 1993, Pubmed
Molenaar, Differential expression of the Groucho-related genes 4 and 5 during early development of Xenopus laevis. 2000, Pubmed , Xenbase
Moody, Cell lineage analysis in Xenopus embryos. 2000, Pubmed , Xenbase
Nybakken, A genome-wide RNA interference screen in Drosophila melanogaster cells for new components of the Hh signaling pathway. 2005, Pubmed
Ohto, Cooperation of six and eya in activation of their target genes through nuclear translocation of Eya. 1999, Pubmed
Oliver, Six3, a murine homologue of the sine oculis gene, demarcates the most anterior border of the developing neural plate and is expressed during eye development. 1995, Pubmed
Ozaki, Six1 controls patterning of the mouse otic vesicle. 2004, Pubmed
Ozaki, Six4, a putative myogenin gene regulator, is not essential for mouse embryonal development. 2001, Pubmed
Pandur, Xenopus Six1 gene is expressed in neurogenic cranial placodes and maintained in the differentiating lateral lines. 2000, Pubmed , Xenbase
Patterson, Hox11-family genes XHox11 and XHox11L2 in xenopus: XHox11L2 expression is restricted to a subset of the primary sensory neurons. 1999, Pubmed , Xenbase
Peretz, Expression of the Drosophila melanogaster GADD45 homolog (CG11086) affects egg asymmetric development that is mediated by the c-Jun N-terminal kinase pathway. 2007, Pubmed
Pfister, A 4-bp insertion in the eya-homologous region (eyaHR) of EYA4 causes hearing impairment in a Hungarian family linked to DFNA10. 2002, Pubmed
Pignoni, The eye-specification proteins So and Eya form a complex and regulate multiple steps in Drosophila eye development. 1997, Pubmed
Pinna, Protein kinase CK2 ("casein kinase-2") and its implication in cell division and proliferation. 1997, Pubmed
Raju, Characterization and developmental expression of Tlx-1, the murine homolog of HOX11. 1993, Pubmed
Roberts, Hox11 controls the genesis of the spleen. 1994, Pubmed
Roberts, Development expression of Hox11 and specification of splenic cell fate. 1995, Pubmed
Rodríguez Soriano, Branchio-oto-renal syndrome. 2003, Pubmed
Rohrmoser, Interdependence of Pes1, Bop1, and WDR12 controls nucleolar localization and assembly of the PeBoW complex required for maturation of the 60S ribosomal subunit. 2007, Pubmed
Roose, The Xenopus Wnt effector XTcf-3 interacts with Groucho-related transcriptional repressors. 1998, Pubmed , Xenbase
Rual, Towards a proteome-scale map of the human protein-protein interaction network. 2005, Pubmed
Ruf, SIX1 mutations cause branchio-oto-renal syndrome by disruption of EYA1-SIX1-DNA complexes. 2004, Pubmed
Sahly, The zebrafish eya1 gene and its expression pattern during embryogenesis. 1999, Pubmed
Sato, Conserved expression of mouse Six1 in the pre-placodal region (PPR) and identification of an enhancer for the rostral PPR. 2010, Pubmed , Xenbase
Schlosser, Development of neurogenic placodes in Xenopus laevis. 2000, Pubmed , Xenbase
Schlosser, Molecular anatomy of placode development in Xenopus laevis. 2004, Pubmed , Xenbase
Schlosser, Induction and specification of cranial placodes. 2006, Pubmed , Xenbase
Schlosser, Eya1 and Six1 promote neurogenesis in the cranial placodes in a SoxB1-dependent fashion. 2008, Pubmed , Xenbase
Schönberger, Mutation in the transcriptional coactivator EYA4 causes dilated cardiomyopathy and sensorineural hearing loss. 2005, Pubmed
Self, Six2 activity is required for the formation of the mammalian pyloric sphincter. 2009, Pubmed
Serikaku, sine oculis is a homeobox gene required for Drosophila visual system development. 1994, Pubmed
Shirasawa, Rnx deficiency results in congenital central hypoventilation. 2000, Pubmed
Silver, Functional dissection of eyes absent reveals new modes of regulation within the retinal determination gene network. 2003, Pubmed
Sithanandam, The ERBB3 receptor in cancer and cancer gene therapy. 2008, Pubmed
Song, Endogenous protein kinase CK2 participates in Wnt signaling in mammary epithelial cells. 2000, Pubmed
Spitz, Expression of myogenin during embryogenesis is controlled by Six/sine oculis homeoproteins through a conserved MEF3 binding site. 1998, Pubmed
Stramer, Gene induction following wounding of wild-type versus macrophage-deficient Drosophila embryos. 2008, Pubmed
Streit, The preplacodal region: an ectodermal domain with multipotential progenitors that contribute to sense organs and cranial sensory ganglia. 2007, Pubmed
Streit, Early development of the cranial sensory nervous system: from a common field to individual placodes. 2004, Pubmed
Strezoska, Bop1 is a mouse WD40 repeat nucleolar protein involved in 28S and 5. 8S RRNA processing and 60S ribosome biogenesis. 2000, Pubmed
Strezoska, Functional inactivation of the mouse nucleolar protein Bop1 inhibits multiple steps in pre-rRNA processing and blocks cell cycle progression. 2002, Pubmed
Söker, Pleiotropic effects in Eya3 knockout mice. 2008, Pubmed , Xenbase
Takekawa, A family of stress-inducible GADD45-like proteins mediate activation of the stress-responsive MTK1/MEKK4 MAPKKK. 1998, Pubmed
Tessmar, A screen for co-factors of Six3. 2002, Pubmed , Xenbase
Uchiyama, CHox11L2, a Hox11 related gene, is expressed in the peripheral nervous system and subpopulation of the spinal cord during chick development. 1999, Pubmed
Vincent, BOR and BO syndromes are allelic defects of EYA1. 1997, Pubmed
Wayne, Mutations in the transcriptional activator EYA4 cause late-onset deafness at the DFNA10 locus. 2001, Pubmed
Wilhelm, Expression of the subunits of protein kinase CK2 during oogenesis in Xenopus laevis. 1995, Pubmed , Xenbase
Willert, Casein kinase 2 associates with and phosphorylates dishevelled. 1997, Pubmed
Xia, Analysis of the expression pattern of Ebp1, an ErbB-3-binding protein. 2001, Pubmed
Xu, Eya1 is required for the morphogenesis of mammalian thymus, parathyroid and thyroid. 2002, Pubmed
Xu, Mouse Eya genes are expressed during limb tendon development and encode a transcriptional activation function. 1997, Pubmed
Xu, Eya1-deficient mice lack ears and kidneys and show abnormal apoptosis of organ primordia. 1999, Pubmed
Xu, Six1 is required for the early organogenesis of mammalian kidney. 2003, Pubmed
Yaklichkin, FoxD3 and Grg4 physically interact to repress transcription and induce mesoderm in Xenopus. 2007, Pubmed , Xenbase
Yoo, Interaction of the PA2G4 (EBP1) protein with ErbB-3 and regulation of this binding by heregulin. 2000, Pubmed
Zhang, Alterations in cell growth and signaling in ErbB3 binding protein-1 (Ebp1) deficient mice. 2008, Pubmed
Zheng, The role of Six1 in mammalian auditory system development. 2003, Pubmed
Zhu, Six3-mediated auto repression and eye development requires its interaction with members of the Groucho-related family of co-repressors. 2002, Pubmed
de la Calle-Mustienes, Xiro homeoproteins coordinate cell cycle exit and primary neuron formation by upregulating neuronal-fate repressors and downregulating the cell-cycle inhibitor XGadd45-gamma. 2002, Pubmed , Xenbase