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Dev Biol 2009 May 15;3292:338-49. doi: 10.1016/j.ydbio.2009.03.007.
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Syndecan-1 regulates BMP signaling and dorso-ventral patterning of the ectoderm during early Xenopus development.

Olivares GH , Carrasco H , Aroca F , Carvallo L , Segovia F , Larraín J .

Extracellular regulation of growth factor signaling is a key event for embryonic patterning. Heparan sulfate proteoglycans (HSPG) are among the molecules that regulate this signaling during embryonic development. Here we study the function of syndecan1 (Syn1), a cell-surface HSPG expressed in the non-neural ectoderm during early development of Xenopus embryos. Overexpression of Xenopus Syn1 (xSyn1) mRNA is sufficient to reduce BMP signaling, induce chordin expression and rescue dorso-ventral patterning in ventralized embryos. Experiments using chordin morpholinos established that xSyn1 mRNA can inhibit BMP signaling in the absence of chordin. Knockdown of xSyn1 resulted in a reduction of BMP signaling and expansion of the neural plate with the concomitant reduction of the non-neural ectoderm. Overexpression of xSyn1 mRNA in xSyn1 morphant embryos resulted in a biphasic effect, with BMP being inhibited at high concentrations and activated at low concentrations of xSyn1. Interestingly, the function of xSyn1 on dorso-ventral patterning and BMP signaling is specific for this HSPG. In summary, we report that xSyn1 regulates dorso-ventral patterning of the ectoderm through modulation of BMP signaling.

PubMed ID: 19303002
Article link: Dev Biol

Species referenced: Xenopus laevis
Genes referenced: cat.2 chrd.1 krt12.4 sdc1 sdc2 sox2 syn1 szl
Morpholinos: bmp2 MO1 bmp4 MO1 chrd.1 MO1 chrd.1 MO2 ctnnb1 MO1 sdc1 MO1 sdc1 MO2

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