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Int J Dev Biol 2008 Jan 01;527:999-1004. doi: 10.1387/ijdb.082586dc.
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Cloning and developmental expression of the soxB2 genes, sox14 and sox21, during Xenopus laevis embryogenesis.

Cunningham DD , Meng Z , Fritzsch B , Casey ES .

The Sox family of transcription factors is thought to regulate gene expression in a wide variety of developmental processes. Here we describe the cloning of the X. laevis orthologs of the SoxB2 family of transcription factors, sox14 and sox21. In situ hybridization revealed that sox14 expression is restricted to the hypothalamus, dorsal thalamus, the optic tectum, a region of the somatic motornucleus in the midbrain and hindbrain, the vestibular nuclei in the hindbrain and a discrete ventral domain in the developing spinal cord. In contrast to the limited expression domain of sox14, sox21 is found throughout the developing central nervous system, including the olfactory placodes, with strongest expression at the boundary between the midbrain and hindbrain.

PubMed ID: 18956331
PMC ID: PMC2587241
Article link: Int J Dev Biol
Grant support: [+]

Species referenced: Xenopus laevis
Genes referenced: adm en2 eomes foxg1 odc1 sox14 sox2 sox21

Article Images: [+] show captions
References [+] :
Bachy, The LIM-homeodomain gene family in the developing Xenopus brain: conservation and divergences with the mouse related to the evolution of the forebrain. 2001, Pubmed, Xenbase