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Gene Expr Patterns 2004 May 01;43:303-8. doi: 10.1016/j.modgep.2003.10.006.
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Regulated gene expression of hyaluronan synthases during Xenopus laevis development.

Nardini M , Ori M , Vigetti D , Gornati R , Nardi I , Perris R .

Here reported is the developmental gene expression pattern of the three known vertebrate hyaluronan synthases (XHas1, XHas2 and XHas3) and a comparative analysis of their mRNAs spatio-temporal distribution during Xenopus laevis development. We found that while XHas2 shows a steady-state expression from gastrula to late tailbud stage, XHas1 is mainly present in the early phases of development while XHas3 is predominantly transcribed in tailbud embryos. XHas1, XHas2 and XHas3 show distinct tissue expression patterns. In particular, XHas1 is localized in ectodermal derivatives and in cranial neural crest cells, whereas XHas2 is mainly found in mesoderm-derived structures and in trunk neural crest cells. Moreover, the expression pattern of XHas2 overlaps that of MyoD in cells committed to a muscle fate. Unlike the other hyaluronan synthases, XHas3 mRNA distribution is very restricted. In particular, XHas3 is expressed in the otic vesicles and closely follows the inner ear development. In conclusion, XHas1, XHas2 and XHas3 mRNAs have distinct and never overlapping spatial expression domains, which would suggest that these three enzymes may play different roles during embryogenesis.

PubMed ID: 15053979
Article link: Gene Expr Patterns

Species referenced: Xenopus laevis
Genes referenced: foxd3 has1 has2 has3 lhx3 myod1 odc1 slc12a3 sox9

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