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Dev Biol 2007 Nov 15;3112:554-65. doi: 10.1016/j.ydbio.2007.09.012.
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XGRIP2.1 is encoded by a vegetally localizing, maternal mRNA and functions in germ cell development and anteroposterior PGC positioning in Xenopus laevis.

Tarbashevich K , Koebernick K , Pieler T .

The Xenopus germ line is derived from a specialized region in the vegetal hemisphere of the oocyte, the germ plasm. Several maternal transcripts harboured in this region have been connected to the process of germ cell specification. We identified and functionally characterized a novel vegetally localizing mRNA encoding a glutamate receptor interacting protein (GRIP) family member in Xenopus, termed XGRIP2.1. XGRIP2.1 is specifically associated with the germ plasm and PGCs throughout Xenopus embryogenesis. Morpholino-mediated knockdown and overexpression of a putative dominant negative XGRIP2.1 protein fragment reduced average PGC numbers and interfered with the proper anteroposterior positioning of PGCs at tailbud stages. Thus, our results suggest that XGRIP2.1 is required for normal PGC development and migration in Xenopus.

PubMed ID: 17936745
Article link: Dev Biol

Species referenced: Xenopus laevis
Genes referenced: dazl grip1 grip2 myod1 pgat pgc tbx2
Morpholinos: grip2 MO1 grip2 MO2

Phenotypes: Xla Wt + grip2 MO (Fig 2F) [+]

Article Images: [+] show captions