Xenbase is undergoing scheduled maintenance Wednesday, June 14 and Thursday, June 15, 2023. Xenbase will be unavailable on those days.

Click on this message to dismiss it.
Click here to close Hello! We notice that you are using Internet Explorer, which is not supported by Xenbase and may cause the site to display incorrectly. We suggest using a current version of Chrome, FireFox, or Safari.
Dev Cell 2007 Aug 01;132:226-41. doi: 10.1016/j.devcel.2007.07.001.
Show Gene links Show Anatomy links

The secreted serine protease xHtrA1 stimulates long-range FGF signaling in the early Xenopus embryo.

Hou S , Maccarana M , Min TH , Strate I , Pera EM .

We found that the secreted serine protease xHtrA1, expressed in the early embryo and transcriptionally activated by FGF signals, promotes posterior development in mRNA-injected Xenopus embryos. xHtrA1 mRNA led to the induction of secondary tail-like structures, expansion of mesoderm, and formation of ectopic neurons in an FGF-dependent manner. An antisense morpholino oligonucleotide or a neutralizing antibody against xHtrA1 had the opposite effects. xHtrA1 activates FGF/ERK signaling and the transcription of FGF genes. We show that Xenopus Biglycan, Syndecan-4, and Glypican-4 are proteolytic targets of xHtrA1 and that heparan sulfate and dermatan sulfate trigger posteriorization, mesoderm induction, and neuronal differentiation via the FGF signaling pathway. The results are consistent with a mechanism by which xHtrA1, through cleaving proteoglycans, releases cell-surface-bound FGF ligands and stimulates long-range FGF signaling.

PubMed ID: 17681134
Article link: Dev Cell

Species referenced: Xenopus laevis
Genes referenced: bgn bmp4 egr2 en2 fgf4 fgf8 foxg1 gpc1 gpc4 hspa9 htra1 ins krt12.4 mapk1 myod1 nkx2-5 nppa otx2 prss1 rax sdc4 shh snai2 sox2 szl tbxt tubb2b
GO keywords: fibroblast growth factor receptor signaling pathway [+]
Morpholinos: htra1 MO1

Article Images: [+] show captions
References :
Gallagher, Messages in the matrix: proteoglycans go the distance. 2007, Pubmed, Xenbase