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Birth Defects Res C Embryo Today 2004 Jun 01;722:124-39. doi: 10.1002/bdrc.20011.
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A slug, a fox, a pair of sox: transcriptional responses to neural crest inducing signals.

Heeg-Truesdell E , LaBonne C .

The neural crest, a cell type found only in vertebrate embryos, gives rise to the structures of the skull and face and most of the peripheral nervous system, as well as other cell types characteristic of vertebrates. These cells are of great clinical significance and a wide variety of congenital defects are due to aberrant neural crest development. Increasing numbers of studies are contributing to our understanding of how this group of cells form and differentiate during normal development. Wnt, FGF, BMP, and Notch-mediated signals all have essential roles in this process, and several of these signals appear to play multiple temporally distinct roles. Changes in the response of neural crest cells to the same signal over time may be mediated, in part, by an ever-changing cocktail of transcription factors expressed within these cells. Neural crest development is thus a complex multistep process, and elucidating the molecular mechanisms that mediate distinct aspects of this process will require that we determine the role of each of these factors alone and in combination. Here, we review some recent advances in our understanding of the signals and downstream transcription factors involved in neural crest cell formation.

PubMed ID: 15269887
Article link: Birth Defects Res C Embryo Today

Species referenced: Xenopus
Genes referenced: ap2a1 dll1 ets1 fgf2 foxd3 hes4 id2 itk jag1 mitf myc notch1 pax3 snai1 snai2 sox10 sox9 tfap2a twist1 zic1

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