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Dev Biol 2004 Aug 01;2721:176-90. doi: 10.1016/j.ydbio.2004.04.030.
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Cardiac neural crest ablation alters Id2 gene expression in the developing heart.

Martinsen BJ , Frasier AJ , Baker CV , Lohr JL .

Id proteins are negative regulators of basic helix-loop-helix gene products and participate in many developmental processes. We have evaluated the expression of Id2 in the developing chick heart and found expression in the cardiac neural crest, secondary heart field, outflow tract, inflow tract, and anterior parasympathetic plexus. Cardiac neural crest ablation in the chick embryo, which causes structural defects of the cardiac outflow tract, results in a significant loss of Id2 expression in the outflow tract. Id2 is also expressed in Xenopus neural folds, branchial arches, cardiac outflow tract, inflow tract, and splanchnic mesoderm. Ablation of the premigratory neural crest in Xenopus embryos results in abnormal formation of the heart and a loss of Id2 expression in the heart and splanchnic mesoderm. This data suggests that the presence of neural crest is required for normal Id2 expression in both chick and Xenopus heart development and provides evidence that neural crest is involved in heart development in Xenopus embryos.

PubMed ID: 15242799
Article link: Dev Biol

Species referenced: Xenopus laevis
Genes referenced: id2 myh1 snai2 tbx2
Antibodies: Myh1 Ab1

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