J Embryol Exp Morphol 1975 Feb 01;331:147-57.

Local autonomy of gastrulation movements after dorsal lip removal in two anuran amphibians.

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The time-course of the remaining gastrulation movements has been investigated after removal of the dorsal lip, the presumptive foregut endoderm and the anterior mid-dorsal mesoderm as a plug-shaped mass of cells from beginning gastrulae of Xenopus laevis and Bombina orientalis. This embryonic region has been previously studied in its role as an organizer, when grafted into a host gastrula marginal zone. There is usually no effect of the removal of these cells, the first morphogenetically active ones, either upon rate of subsequent completion of the external aspects of gastrulation, or upon the internal evolution of the presumptive mesodermal mantle. This finding is discussed in connexion with results of a previous paper on pattern formation in early Xenopus development, since it may help to distinguish between possible types of explanation for those results.

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