Bourdelas A et al. (2004), Identification of distinct genes with restricte...

XB-ART-2914

Gene Expr Patterns 2004 Oct 01;46:695-9. doi: 10.1016/j.modgep.2004.04.004.

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Identification of distinct genes with restricted expression in the somitic mesoderm in Xenopus embryo.

Bourdelas A , Li HY , Boucaut JC , Shi DL .

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We have used whole-mount in situ hybridisation to identify genes expressed in the somitic mesoderm during Xenopus early development. We report here the analysis of eight genes whose expression pattern has not been described previously. They include the Xenopus homologues of eukaryotic initiation factor 2beta, methionine adenosyltransferase II, serine dehydratase, alpha-adducin, oxoglutarate dehydrogenase, fragile X mental retardation syndrome related protein 1, monocarboxylate transporter and voltage-dependent anion channel 1. Interestingly, these genes exhibit very dynamic expression pattern during early development. At early gastrula stages several genes do not show localised expression pattern, while other genes are expressed in the marginal mesoderm or in ectoderm. As development proceeds, the expression of these genes is gradually restricted to different compartments of somite. This study thus reveals an unexpected dynamic expression pattern for various genes with distinct function in vertebrates.

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Species referenced: Xenopus
Genes referenced: add1 eif2b1 fxr1 mat2a myod1 ogdh sds slc16a1 vdac1

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	Fig. 1. Expression pattern of eIF2β (A–F), methionine adenosyltransferase II (G–I), oxoglutarate dehydrogenase (J–L), FXR1 (M–O) and Vdac (P–R) at neurula and tail-bud stages. This group of genes does not exhibit regionalised expression at gastrula stage, but show both redundant and distinct expression in the somitic mesoderm. NT, neural tube; not, notochord. Arrows in (F) and (I) indicate the boundary of each somite.
	Fig. 2. Expression pattern of serine dehydratase (A–D), XMyoD (E, F), α-adducin (G–I) and monocarboxylate transporter (J–L) in stage 11.5 gastrula (A, G, J), stage 20 neurula (B, H, K) and stage 35 tail-bud (C, E, F, I, L) embryos. Note that these genes exhibit very dynamic expression pattern during early development. They also show distinct expression in the somites. CG, cement gland; h, heart primordium. Arrows indicate the boundary of each somite.
	Xenopus laevis methionine adenosyltransferase II, alpha expression at stage 32