Click here to close Hello! We notice that you are using Internet Explorer, which is not supported by Xenbase and may cause the site to display incorrectly. We suggest using a current version of Chrome, FireFox, or Safari.
EMBO J 1987 Mar 01;63:667-73. doi: 10.1002/j.1460-2075.1987.tb04806.x.
Show Gene links Show Anatomy links

Xenopus cytoskeletal actin and human c-fos gene promoters share a conserved protein-binding site.

Mohun T , Garrett N , Treisman R .

Xenopus laevis cytoskeletal actin gene promoters contain a 20-bp sequence homologous to the serum response element (SRE) required for transient human c-fos gene transcription in response to serum factors. Both sequences bind the same factor in HeLa cell extracts, as shown by binding competition, DNase I and dimethylsulphate (DMS) protection and DMS interference assays. A similar protein is present in Xenopus laevis oocytes. Sequences containing the SRE homology are essential for constitutive activity of the actin promoter in both Xenopus and mouse cells, and a synthetic SRE functions as a promoter element in these cells. In mouse cells, transcription of both transfected Xenopus actin and actin/c-fos fusion genes is activated following serum stimulation. These data suggest that the SRE and its cognate protein form part of a regulatory pathway that has been highly conserved during evolution.

PubMed ID: 3582369
PMC ID: PMC553449
Article link: EMBO J

Species referenced: Xenopus laevis
Genes referenced: actl6a fos

References [+] :
Bergsma, Novel chicken actin gene: third cytoplasmic isoform. 1985, Pubmed