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Cell 1987 Aug 28;505:749-58.
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A homeobox-containing marker of posterior neural differentiation shows the importance of predetermination in neural induction.

Sharpe CR , Fritz A , De Robertis EM , Gurdon JB .

A homeobox sequence has been used to isolate a new Xenopus cDNA, named XIHbox6. A short probe from this gene serves as an early marker of posterior neural differentiation in the Xenopus nervous system. The gene recognized by this cDNA sequence is first transcribed at the late gastrula stage and solely in the posterior neural cells. The gene is expressed when ectodermal and mesodermal tissues of an early gastrula are placed in contact, but not by either tissue cultured on its own. However, gene expression is most easily inducible in ectoderm from the dorsal region, i.e., in ectoderm normally destined to form neural structures. This establishes the principle, in contrast to previous belief, that the induction of the embryonic nervous system involves a predisposition of the ectoderm and does not depend entirely on an interaction with inducing mesoderm.

PubMed ID: 2441873
Article link: Cell
Grant support: [+]

Species referenced: Xenopus
Genes referenced: hoxb9 hoxc9 hoxc9-like