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Acta Histochem 1991 Jan 01;902:135-40.
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Localization of calmodulin in epidermis and skin glands: a comparative immunohistological investigation in different vertebrate species.

Wollina U , Wevers A , Mahrle G .

The study deals with the immunolocalization of calmodulin-reactive epithelial cells in different vertebrates (Tinca tinca, Ambystoma mexicanum, Xenopus laevis, Rana ridibunda, Columba domestica, Sus scrofa domestica, Homo sapiens sapiens). The immunoperoxidase technique was performed on acetone fixed frozen sections using monoclonal (BF8) and polyclonal (ACAM) anti-calmodulin antibodies. We were able to differentiate 2 major types of staining patterns: 1. A more superficial epidermal staining in species adapted to an aqueous environment and 2. a staining along the epidermal-dermal junction in species adapted to a terrestrial environment. It seems most likely that epithelial cells immunoreactive for calmodulin are involved in skin permeability control.

PubMed ID: 1718122
Article link: Acta Histochem

Species referenced: Xenopus laevis
Genes referenced: calm1 calm2 calml4