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XB-ART-25042
FEBS Lett 1991 Feb 25;2792:289-94.
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Zinc is required for folding and binding of a single zinc finger to DNA.

Lee MS , Gottesfeld JM , Wright PE .


Abstract
A synthetic peptide corresponding to zinc finger 31 of the Xenopus protein Xfin adopts a folded conformation in the presence of zinc. The same peptide in the absence of zinc is not folded in a stable tertiary conformation, as determined by NMR. Binding experiments have shown that the peptide binds non-specifically to DNA only in the presence of zinc. Moreover, competitive DNA binding experiments indicate interaction with 3.9 +/- 0.4 base pairs.

PubMed ID: 2001741
Article link: FEBS Lett
Grant support: [+]

Species referenced: Xenopus
Genes referenced: znf208