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Science 1992 Jul 24;2575069:542-5.
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Planar induction of anteroposterior pattern in the developing central nervous system of Xenopus laevis.

Doniach T , Phillips CR , Gerhart JC .

It has long been thought that anteroposterior (A-P) pattern in the vertebrate central nervous system is induced in the embryo's dorsal ectoderm exclusively by signals passing vertically from underlying, patterned dorsal mesoderm. Explants from early gastrulae of the frog Xenopus laevis were prepared in which vertical contact between dorsal ectoderm and mesoderm was prevented but planar contact was maintained. In these, four position-specific neural markers (engrailed-2, Krox-20, XlHbox 1, and XlHbox 6) were expressed in the ectoderm in the same A-P order as in the embryo. Thus, planar signals alone, following a path available in the normal embryo, can induce A-P neural pattern.

PubMed ID: 1636091
Article link: Science
Grant support: [+]

Species referenced: Xenopus laevis
Antibodies: En2 Ab1