XB-ART-23176
Brain Res Dev Brain Res
1992 Nov 20;701:134-8. doi: 10.1016/0165-3806(92)90111-9.
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Expression of carnosine-like immunoreactivity during retinal development in the clawed frog (Xenopus laevis).
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The development of neurons immunoreactive to carnosine (beta-alanyl-L-histidine) was studied in the retina of Xenopus laevis during the premetamorphic period. Carnosine-like immunoreactivity was detected in photoreceptors from stage 39/40 (according to Nieuwkoop and Faber [Normal Tables of Xenopus laevis (Daudin), Elsevier, Amsterdam, 1956]) and in bipolar cells and their processes in the inner plexiform layer from stage 44/45. At all the developmental stages studied, neuroepithelial cells at the ciliary margin were completely unstained, suggesting that carnosine is only present in postmitotic retinal neurons. This study demonstrates a correlation between the times of appearance of carnosine-like immunoreactivity during retinal development and the onset of visual function.
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