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XB-ART-21667
FEBS Lett 1994 Jan 24;3381:107-11.
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Cloning and functional expression of a cardiac inward rectifier K+ channel.

Ishii K , Yamagishi T , Taira N .


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We have isolated a cDNA coding for an inward rectifier K+ channel (RBHIK1) from rabbit heart. The cloned cDNA encodes a protein of 427 amino acids with two putative transmembrane segments. The primary structure of RBHIK1 is highly homologous to that of IRK1 which is an inward rectifier K+ channel recently cloned from mouse macrophage by expression cloning. When expressed in Xenopus oocytes, RBHIK1 current showed strong inward rectification and was inhibited by extracellular Ba2+ and Cs+. RNA blot analysis revealed the expression of RBHIK1 mRNA in various rabbit tissues, especially high level in the ventricular muscle.

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Species referenced: Xenopus
Genes referenced: kcnj12 kcnj2