Click here to close Hello! We notice that you are using Internet Explorer, which is not supported by Xenbase and may cause the site to display incorrectly. We suggest using a current version of Chrome, FireFox, or Safari.
XB-ART-20420
Neuroreport 1994 Dec 20;518:2501-5. doi: 10.1097/00001756-199412000-00024.
Show Gene links Show Anatomy links

Molecular cloning and expression of a human heart inward rectifier potassium channel.

Raab-Graham KF , Radeke CM , Vandenberg CA .


Abstract
We have isolated a cDNA encoding an inwardly rectifying K+ channel (HH-IRK1) from human heart. The cDNA codes for a 427-amino acid protein, with two putative transmembrane domains and an H5 region. The primary structure of HH-IRK1 is homologous to that of the IRK1 channel cloned from a mouse macrophage-like cell line. Functional expression in Xenopus oocytes showed that HH-IRK1 is a K+ channel with strong inward rectification, blocked by extracellular Ba2+ and Cs+, and with a single-channel conductance of 30 pS. Northern analysis showed HH-IRK1 transcripts in human heart, brain, skeletal muscle, placenta, lung and kidney. HH-IRK1 was mapped to human chromosome 17.

PubMed ID: 7696590
Article link: Neuroreport
Grant support: [+]

Species referenced: Xenopus
Genes referenced: kcnj2