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Mech Dev 1995 Apr 01;502-3:103-17.
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Dynamic and differential Oct-1 expression during early Xenopus embryogenesis: persistence of Oct-1 protein following down-regulation of the RNA.

Veenstra GJ , Beumer TL , Peterson-Maduro J , Stegeman BI , Karg HA , van der Vliet PC , Destrée OH .

As a first step towards the elucidation of the role of the transcription factor Oct-1 in development, we prepared a monoclonal antibody to study the spatio-temporal distribution of Oct-1 protein in vivo. Here we report differential expression of the Oct-1 gene in the Xenopus embryo both at the RNA and the protein level. Transcripts and protein are detected in ectodermal and mesodermal cell lineages, in which the expression exhibits a pattern of progressive spatial restriction in the course of development. The Oct-1 expression as reported here is not correlated with cell density or cell proliferation in the embryo. Our results suggest a role of Oct-1 in the specification and differentiation of neuronal and neural crest cells. In many other cells, the developmental decision to down regulate Oct-1 is delayed, probably due to a high stability of the protein.

PubMed ID: 7542467

Species referenced: Xenopus laevis
Genes referenced: dct pcna pou2f1 tbx2
Antibodies: pou2f1 Ab1

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