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Genes Dev 1995 May 01;99:1046-58. doi: 10.1101/gad.9.9.1046.
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Raf1 interaction with Cdc25 phosphatase ties mitogenic signal transduction to cell cycle activation.

Galaktionov K , Jessus C , Beach D .

The Ras and Raf1 proto-oncogenes transduce extracellular signals that promote cell growth. Cdc25 phosphatases activate the cell division cycle by dephosphorylation of critical threonine and tyrosine residues within the cyclin-dependent kinases. We show here that Cdc25 phosphatase associates with raf1 in somatic mammalian cells and in meiotic frog oocytes. Furthermore, Cdc25 phosphatase can be activated in vitro in a Raf1-dependent manner. We suggest that activation of the cell cycle by the Ras/Raf1 pathways might be mediated in part by Cdc25.

PubMed ID: 7744247
Article link: Genes Dev

Species referenced: Xenopus
Genes referenced: cdc25c raf1 rasgrf1