Click here to close Hello! We notice that you are using Internet Explorer, which is not supported by Xenbase and may cause the site to display incorrectly. We suggest using a current version of Chrome, FireFox, or Safari.
XB-ART-19770
Genes Dev 1995 May 01;99:1046-58. doi: 10.1101/gad.9.9.1046.
Show Gene links Show Anatomy links

Raf1 interaction with Cdc25 phosphatase ties mitogenic signal transduction to cell cycle activation.

Galaktionov K , Jessus C , Beach D .


???displayArticle.abstract???
The Ras and Raf1 proto-oncogenes transduce extracellular signals that promote cell growth. Cdc25 phosphatases activate the cell division cycle by dephosphorylation of critical threonine and tyrosine residues within the cyclin-dependent kinases. We show here that Cdc25 phosphatase associates with raf1 in somatic mammalian cells and in meiotic frog oocytes. Furthermore, Cdc25 phosphatase can be activated in vitro in a Raf1-dependent manner. We suggest that activation of the cell cycle by the Ras/Raf1 pathways might be mediated in part by Cdc25.

???displayArticle.pubmedLink??? 7744247
???displayArticle.link??? Genes Dev


Species referenced: Xenopus
Genes referenced: cdc25c raf1 rasgrf1