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Development 1995 Aug 01;1218:2337-47.
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Distinct expression and shared activities of members of the hedgehog gene family of Xenopus laevis.

Ekker SC , McGrew LL , Lai CJ , Lee JJ , von Kessler DP , Moon RT , Beachy PA .

The hedgehog family of signaling proteins is associated with a variety of spatial patterning activities in insects and vertebrates. Here we show that new members of this family isolated from Xenopus laevis are expressed embryonically in patterns suggestive of roles in patterning in the ectoderm, nervous system and somites. Banded hedgehog is expressed throughout the neural plate and subsequently in both the nervous system and in the dermatome of somites. Cephalic hedgehog is expressed in anterior ectoderm and endodermal structures, and sonic hedgehog is expressed in patterns which parallel those in other species. Injection of RNAs encoding Xenopus hedgehogs induces ectopic cement gland formation in embryos. Similar to reported activities of noggin and follistatin, Xenopus hedgehogs share a common ability to induce cement glands in animal cap explants. However, hedgehog activities in naive ectoderm appear capable of acting independently of noggin and follistatin since, although all three are induced by activin in animal cap explants, X-hh expression does not induce noggin or follistatin.

PubMed ID: 7671800
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Species referenced: Xenopus laevis
Genes referenced: ag1 dhh fst hesx1 ihh nog shh
Antibodies: Somite Ab1

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