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XB-ART-18087
Biochem Biophys Res Commun 1996 Jun 14;2232:474-9.
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Functional expression and cellular mRNA localization of a G protein-activated K+ inward rectifier isolated from rat brain.

Dissmann E , Wischmeyer E , Spauschus A , Pfeil DV , Karschin C , Karschin A .


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We have cloned by homology screening from a rat brain cDNA library a GIRK3-type (Kir 3.3) inwardly rectifying K+ channel subunit with high structural similarity to other subfamily members whose activity is thought to be controlled by receptor-stimulated G proteins. When heterologously expressed both in Xenopus oocytes and in mammalian COS-7 cells, rbGIRK3 subunits individually fail to form functional channels. In contrast, when coexpressed with other GIRK subunits, rbGIRK3 gives rise to prominent currents which are enhanced by the stimulation of coexpressed 5-HT1A receptors. In situ hybridizations show that of all GIRK subunits rbGIRK3 is most widely distributed and strongly expressed throughout the rat brain and thus may play an important role in central signal processing.

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Species referenced: Xenopus
Genes referenced: htr1a kcnj22 kcnj3 kcnj9