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Science 1996 Jul 19;2735273:355-8. doi: 10.1126/science.273.5273.355.
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The secreted product of Xenopus gene lunatic Fringe, a vertebrate signaling molecule.

Wu JY , Wen L , Zhang WJ , Rao Y .

Signaling molecules are essential for vertebrate embryonic development. Here, two Xenopus homologs of the Drosophila gene fringe, lunatic Fringe (lFng) and radical Fringe (rFng), were identified and the protein product of lFng further characterized. The messenger RNA of lFng is supplied as a maternal message. Its product is a precursor protein consisting of pre-, pro-, and mature regions. The mature lunatic Fringe protein is secreted extracellularly, and it induced mesodermal tissue formation in animal cap assays. These results indicate that secreted lunatic Fringe can induce mesoderm and reveal that the Fringe proteins are a family of vertebrate signaling molecules.

PubMed ID: 8662522
PMC ID: PMC2080353
Article link: Science
Grant support: [+]

Species referenced: Xenopus
Genes referenced: lfng rfng

References [+] :
Amaya, Expression of a dominant negative mutant of the FGF receptor disrupts mesoderm formation in Xenopus embryos. 1991, Pubmed, Xenbase