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XB-ART-17597
Biochem Biophys Res Commun 1996 Oct 03;2271:20-6. doi: 10.1006/bbrc.1996.1461.
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Inhibition of Raf/MAPK signaling in Xenopus oocyte extracts by Raf-1-specific peptides.

Radziwill G , Steinhusen U , Aitken A , Moelling K .


Abstract
Raf-1 is an upstream element of the mitogen-activated protein kinase (MAPK) pathway which leads to cell proliferation and differentiation. In this study Raf-1 derived peptides comprising the conserved amino acid residues Arg89 and Ser259, involved in binding of activated Ras and 14-3-3 proteins, respectively, were shown to interfere with MAPK activation in extracts from immature Xenopus oocytes. Lipids prepared from oocyte extracts can stimulate MAPK in a Ras- and protein kinase C-independent manner. This lipid-induced MAPK activation is blocked by a Raf-1 derived peptide comprising Ser259.

PubMed ID: 8858097
Article link: Biochem Biophys Res Commun


Species referenced: Xenopus
Genes referenced: mapk1 raf1