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Int J Dev Biol 2005 Jan 01;494:401-8. doi: 10.1387/ijdb.052005dl.
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The role of XTRAP-gamma in Xenopus pronephros development.

Li DH , Chan T , Satow R , Komazaki S , Hashizume K , Asashima M .

We isolated and characterized the Xenopus translocon-associated protein XTRAP-gamma, one of four subunits of the translocon-associated protein complex. TRAP has been proposed to aid the translocation of nascent polypeptides into the lumen of the endoplasmic reticulum, but this has not been demonstrated until now. XTRAP-gamma was specifically expressed in the pronephros tubules of Xenopus laevis from stage 25 during kidney development. Antisense morpholino oligonucleotide-mediated knockdown of XTRAP-gamma suppressed tubulogenesis and decreased expression of the pronephros marker genes Pax-2 and Wnt-4. XTRAP-gamma morpholinos also inhibited differentiation of the pronephros in activin/retinoic acid-treated animal caps. We conclude that XTRAP-gamma plays an important role in the process of pronephros differentiation.

PubMed ID: 15968585
Article link: Int J Dev Biol

Species referenced: Xenopus laevis
Genes referenced: lhx1 pax2 pax8 ssr3 wnt4
Antibodies: Kidney Ab2
Morpholinos: ssr3 MO1

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