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Exp Cell Res 1997 Aug 25;2351:227-37. doi: 10.1006/excr.1997.3672.
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Antibody cross-linking of the thymocyte-specific cell surface molecule CTX causes abnormal mitosis and multinucleation of tumor cells.

Robert J , Brown DM , Pasquier LD , Cohen N .

The thymocyte-specific cell surface molecule CTX is a developmentally regulated type I transmembrane protein of the immunoglobulin superfamily which, in the amphibian Xenopus, is exclusively expressed by a large fraction of cortical thymocytes and by different cell lines derived from independent spontaneous thymic tumors. Antibody cross-linking of CTX in vitro inhibits the growth of tumor cells and causes morphological alterations. Cells divide abnormally, accumulate in the G2/M phase of the cell cycle, and become multinucleated. This demonstrates, for the first time, that multinucleation can be induced by specifically cross-linking a cell surface molecule.

PubMed ID: 9281372
Article link: Exp Cell Res
Grant support: [+]

Species referenced: Xenopus
Genes referenced: vsig1
Antibodies: Cth Ab1