Click here to close Hello! We notice that you are using Internet Explorer, which is not supported by Xenbase and may cause the site to display incorrectly. We suggest using a current version of Chrome, FireFox, or Safari.
Nat Genet 1998 Jun 01;192:187-91. doi: 10.1038/561.
Show Gene links Show Anatomy links

Methylated DNA and MeCP2 recruit histone deacetylase to repress transcription.

Jones PL , Veenstra GJ , Wade PA , Vermaak D , Kass SU , Landsberger N , Strouboulis J , Wolffe AP .

CpG methylation in vertebrates correlates with alterations in chromatin structure and gene silencing. Differences in DNA-methylation status are associated with imprinting phenomena and carcinogenesis. In Xenopus laevis oocytes, DNA methylation dominantly silences transcription through the assembly of a repressive nucleosomal array. Methylated DNA assembled into chromatin binds the transcriptional repressor MeCP2 which cofractionates with Sin3 and histone deacetylase. Silencing conferred by MeCP2 and methylated DNA can be relieved by inhibition of histone deacetylase, facilitating the remodelling of chromatin and transcriptional activation. These results establish a direct causal relationship between DNA methylation-dependent transcriptional silencing and the modification of chromatin.

PubMed ID: 9620779
Article link: Nat Genet

Species referenced: Xenopus laevis
Genes referenced: mecp2 sin3a