Click here to close Hello! We notice that you are using Internet Explorer, which is not supported by Xenbase and may cause the site to display incorrectly. We suggest using a current version of Chrome, FireFox, or Safari.
Mech Dev 1999 Jan 01;801:15-27.
Show Gene links Show Anatomy links

Xenopus brain factor-2 controls mesoderm, forebrain and neural crest development.

The forkhead type Brain Factor 2 from mouse and chicken help pattern the forebrain, optic vesicle and kidney. We have isolated a Xenopus homolog (Xbf2) and found that during gastrulation it is expressed in the dorsolateral mesoderm, where it helps specify this territory by downregulating BMP-4 and its downstream genes. Indeed, Xbf2 overexpression caused partial axis duplication. Interference with BMP-4 signaling also occurs in isolated animal caps, since Xbf2 induces neural tissue. Within the neurula forebrain, Xbf2 and the related Xbf1 gene are expressed in the contiguous diencephalic and telencephalic territories, respectively, and each gene represses the other. Finally, Xbf2 seems to participate in the control of neural crest migration. Our data suggest that XBF2 interferes with BMP-4 signaling, both in mesoderm and ectoderm.

PubMed ID: 10096060
Article link: Mech Dev

Species referenced: Xenopus
Genes referenced: bmp4 foxd1 foxg1 gsc lhx1 msx1 myod1 ptgds snai2 sox2 twist1 ventx1.1 ventx1.2 ventx2.1 ventx2.2 wnt8a

Article Images: [+] show captions