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J Cell Biol 2006 Jul 17;1742:301-13. doi: 10.1083/jcb.200602062.
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Paraxial protocadherin mediates cell sorting and tissue morphogenesis by regulating C-cadherin adhesion activity.

Chen X , Gumbiner BM .

Little is known about how protocadherins function in cell adhesion and tissue development. Paraxial protocadherin (PAPC) controls cell sorting and morphogenetic movements in the Xenopus laevis embryo. We find that PAPC mediates these functions by down-regulating the adhesion activity of C-cadherin. Expression of exogenous C-cadherin reverses PAPC-induced cell sorting and gastrulation defects. Moreover, loss of endogenous PAPC results in elevated C-cadherin adhesion activity in the dorsal mesoderm and interferes with the normal blastopore closure, a defect that can be rescued by a dominant-negative C-cadherin mutant. Importantly, activin induces PAPC expression, and PAPC is required for activin-induced regulation of C-cadherin adhesion activity and explant morphogenesis. Signaling through Frizzled-7 is not required for PAPC regulation of C-cadherin, suggesting that C-cadherin regulation and Frizzled-7 signaling are two distinct branches of the PAPC pathway that induce morphogenetic movements. Thus, spatial regulation of classical cadherin adhesive function by local expression of a protocadherin is a novel mechanism for controlling cell sorting and tissue morphogenesis.

PubMed ID: 16847104
PMC ID: PMC2064189
Article link: J Cell Biol
Grant support: [+]

Species referenced: Xenopus laevis
Genes referenced: cad cald1 cdh3 fn1 fzd7 mapk8 pcdh8 pcdh8.2 prss1 rhoa
Antibodies: Cdh3 Ab2 Pcdh8.2 Ab1
Morpholinos: fzd7 MO3 pcdh8.2 MO2 pcdh8.2 MO3

Article Images: [+] show captions
References [+] :
Angst, The cadherin superfamily: diversity in form and function. 2001, Pubmed