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Mech Dev 1999 Dec 01;891-2:75-85. doi: 10.1016/s0925-4773(99)00204-x.
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The POU domain gene, XlPOU 2 is an essential downstream determinant of neural induction.

Matsuo-Takasaki M , Lim JH , Sato SM .

The POU domain gene, XlPOU 2, acts as a transcriptional activator during mid-gastrulation in Xenopus. Overexpression or misexpression of VP16-POU-GR, a fusion protein consisting of the strong activator domain of VP16 and the POU domain of XlPOU 2, results in ectopic expression of the neural-specific genes, nrp-1, en-2, and beta-tubulin. In contrast, overexpressing a dominant-inhibitory form of XlPOU 2 inhibits the chordin-induced neuralization of uncommitted ectoderm, and results in a loss of nrp-1 and en-2 expression in embryos. Furthermore, in uncommitted ectoderm, XlPOU 2 regulates the developmental neural program that includes a number of pre-pattern genes and at least one proneural gene, X-ngnr-1, thus playing a key role during neural determination.

PubMed ID: 10559482
Article link: Mech Dev

Species referenced: Xenopus laevis
Genes referenced: acta4 chrd.1 en2 eng gal.2 neurog2 nrp1 pou3f4 tbxt tubb zic1 zic3

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