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Mech Dev 1999 Dec 01;891-2:161-5. doi: 10.1016/s0925-4773(99)00195-1.
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Characterization of a subfamily of related winged helix genes, XFD-12/12''/12" (XFLIP), during Xenopus embryogenesis.

The fork head domain family of genes defines a growing group of proteins that serve important regulatory functions in pattern-forming events of both invertebrates and vertebrates. Here we add three closely related, novel members to this family in Xenopus laevis, termed XFD-12, XFD-12' and XFD-12". All three genes reveal indistinguishable expression patterns during Xenopus embryogenesis. During gastrulation, XFD-12 type transcripts are detected exclusively in the superficial layer of cells within the Spemann organizer territory. In the open neural plate, XFD-12 type expression defines a row of cells located along the dorsal midline and destined to become the floor plate of the neural tube. After closure of the neural tube, XFD-12 type encoding mRNAs are only detected in the tailtip and a small area located at the midbrain/hindbrain boundary. Within the Spemann organizer and in the floor plate area, expression of XFD-12 type genes is only partially overlapping with XFD-1 expression.

PubMed ID: 10559492
Article link: Mech Dev

Species referenced: Xenopus laevis
Genes referenced: chrd.1 egr2 en2 foxa4 foxd4l1.1 foxd4l1.2 tbx2

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