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Development 2000 Oct 01;12719:4203-16. doi: 10.1242/dev.127.19.4203.
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Hes6 acts in a positive feedback loop with the neurogenins to promote neuronal differentiation.

Koyano-Nakagawa N , Kim J , Anderson D , Kintner C .

During the development of the vertebrate nervous system, neurogenesis is promoted by proneural bHLH proteins such as the neurogenins, which act as potent transcriptional activators of neuronal differentiation genes. The pattern by which these proteins promote neuronal differentiation is thought to be governed by inhibitors, including a class of transcriptional repressors called the WRPW-bHLH proteins, which are similar to Drosophila proteins encoded by hairy and genes in the enhancer of split complex (E-(SPL)-C). Here, we describe the isolation and characterization of Hes6, which encodes a novel WRPW-bHLH protein expressed during neurogenesis in mouse and Xenopus embryos. We show that Hes6 expression follows that of neurogenins but precedes that of the neuronal differentiation genes. We provide several lines of evidence to show that Hes6 expression occurs in developing neurons and is induced by the proneural bHLH proteins but not by the Notch pathway. When ectopically expressed in Xenopus embryos, Hes6 promotes neurogenesis. The properties of Hes6 distinguish it from other members of the WRPW-bHLH family in vertebrates, and suggest that it acts in a positive-feedback loop with the proneural bHLH proteins to promote neuronal differentiation.

PubMed ID: 10976052
Article link: Development

Species referenced: Xenopus laevis
Genes referenced: drg1 eef1a2 elavl3 h2ac21 hes1 hes4 hes5.1 hes5.2 hes6.1 hes6.2 lgals4.2 myt1 neurod1 neurog1 nhlh1 notch1 runx1 snai2 sox10 stmn2 tbx2 tcf3 tubb2b zic2

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