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XB-ART-9966
Eur J Pharmacol 2000 Nov 17;4082:R1-2. doi: 10.1016/s0014-2999(00)00778-0.
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Loreclezole as a simple functional marker for homomeric rho type GABA(C) receptors.

Thomet U , Baur R , Dodd RH , Sigel E .


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GABA(C) receptors are expressed in the whole brain, but predominantly in the retina. They can be identified by their unique pharmacology. The establishment of the entire pharmacology is, however, quite tedious. We show here that loreclezole dose dependently inhibits ionic currents elicited by GABA (gamma-aminobutyric acid) with an IC(50) of about 0.5 microM in homomeric rho1 GABA(C) receptors expressed in Xenopus oocytes. Thus, loreclezole may constitute a functional marker for these receptors.

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Species referenced: Xenopus
Genes referenced: rho rho.2