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Antimicrob Agents Chemother
2000 Dec 01;4412:3473-5. doi: 10.1128/AAC.44.12.3473-3475.2000.
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Short-term exposure to membrane-active antibiotics inhibits Cryptosporidium parvum infection in cell culture.
Giacometti A
,
Cirioni O
,
Del Prete MS
,
Barchiesi F
,
Scalise G
.
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A cell culture system and double fluorogenic staining were used to study the susceptibility of Cryptosporidium parvum to membrane-active antibiotics. Buforin II and magainin II exerted a cytotoxic effect on sporozoites but did not consistently affect oocyst viability. Lasalocid and nigericin demonstrated less activity against sporozoites but reduced the infectivity of oocysts.
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