Click here to close Hello! We notice that you are using Internet Explorer, which is not supported by Xenbase and may cause the site to display incorrectly. We suggest using a current version of Chrome, FireFox, or Safari.
XB-ART-9460
Nat Cell Biol 2001 Mar 01;33:221-7. doi: 10.1038/35060000.
Show Gene links Show Anatomy links

Ran stimulates spindle assembly by altering microtubule dynamics and the balance of motor activities.

Wilde A , Lizarraga SB , Zhang L , Wiese C , Gliksman NR , Walczak CE , Zheng Y .


???displayArticle.abstract???
The guanosine tri-phosphatase Ran stimulates assembly of microtubule spindles. However, it is not known what aspects of the microtubule cytoskeleton are subject to regulation by Ran in mitosis. Here we show that Ran-GTP stimulates microtubule assembly by increasing the rescue frequency of microtubules three- to eightfold. In addition to changing microtubule dynamics, Ran-GTP also alters the balance of motor activities, partly as a result of an increase in the amount of motile Eg5, a plus-end-directed microtubule motor that is essential for spindle formation. Thus, Ran regulates multiple processes that are involved in spindle assembly.

???displayArticle.pubmedLink??? 11231570
???displayArticle.link??? Nat Cell Biol
???displayArticle.grants??? [+]

Species referenced: Xenopus laevis
Genes referenced: kif11 ran

References :
Walczak, Ran hits the ground running. 2001, Pubmed, Xenbase