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XB-ART-9132
FEBS Lett 2001 Apr 20;4951-2:61-5. doi: 10.1016/s0014-5793(01)02365-1.
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Electrophysiological characterization of BmK M1, an alpha-like toxin from Buthus martensi Karsch venom.

Goudet C , Huys I , Clynen E , Schoofs L , Wang DC , Waelkens E , Tytgat J .


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The present study investigates the electrophysiological actions of BmK M1, an alpha-like toxin purified from the venom of the scorpion Buthus martensi Karsch, on voltage-gated Na+ channels. Using the voltage clamp technique, we assessed the BmK M1 activity on the cardiac Na+ channel (hH1) functionally expressed in Xenopus oocytes. The main actions of the toxin are a concentration-dependent slowing of the inactivation process and a hyperpolarizing shift of the steady-state inactivation. This work is the first electrophysiological characterization of BmK M1 on a cloned Na+ channel, demonstrating that this toxin belongs to the class of scorpion alpha-toxins. Our results also show that BmK M1 can be considered as a cardiotoxin.

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