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XB-ART-9064
Biochim Biophys Acta 2001 Feb 16;15173:455-9. doi: 10.1016/s0167-4781(00)00271-2.
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Identification of a murine cysteinyl leukotriene receptor by expression in Xenopus laevis oocytes.

Mollerup J , Jørgensen ST , Hougaard C , Hoffmann EK .


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We report the identification of an EST encoding a murine cysteinyl leukotriene (mCysLT) receptor. LTD4, LTC4 and LTE4 but not LTB4 or various nucleotides activated Ca2+-evoked Cl- currents in mCysLT1 expressing Xenopus laevis oocytes. The response to LTD4 was blocked by MK-571, reduced by pretreatment with pertussis toxin (PTX), and was partly dependent on extracellular Ca2+. The identified murine CysLT1 receptor differs from the hCysLT1 receptor with regard to PTX sensitivity, receptor-mediated Ca2+ influx, and antagonist sensitivity.

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