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J Mol Neurosci
2001 Feb 01;161:21-32. doi: 10.1385/JMN:16:1:21.
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Cloning and characterization of G protein-gated inward rectifier K+ channel (GIRK1) isoforms from heart and brain.
Zhu L
,
Wu X
,
Wu MB
,
Chan KW
,
Logothetis DE
,
Thornhill WB
.
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A G protein-gated inward rectifier potassium (K+) channel (GIRK1a) has been cloned from different tissues (Kubo et al., 1993b; Dascal et al., 1993). Here we report the cloning of three additional novel isoforms of GIRK1a from rat atria and and one from human brain. These isoform cDNAs code for proteins that have identical N-termini, M1-H5-M2 (predicted transmembrane and pore domains), and post-M2 amino acid regions to GIRK1a (1-501 amino acids), but they have shorter C-termini (GIRK1b (1-309), GIRK1c (1-308), GIRK1d (1-235), and GIRK1e (1-253). These results indicated that isoforms were generated by alternative splicing and partial genomic analysis confirmed the presence of exons and introns in the rat GIRK1 gene. RNase protection analysis and immunoblot analysis indicated that the isoforms were expressed in both rat atria and brain but at lower levels versus GIRK1a. The physiological role that the isoforms may play in atrial and brain physiology remains to be determined.
Ashford,
Cloning and functional expression of a rat heart KATP channel.
1994, Pubmed
Ashford,
Cloning and functional expression of a rat heart KATP channel.
1994,
Pubmed
Breitwieser,
Uncoupling of cardiac muscarinic and beta-adrenergic receptors from ion channels by a guanine nucleotide analogue.
,
Pubmed
Doupnik,
The inward rectifier potassium channel family.
1995,
Pubmed
Ho,
Cloning and expression of an inwardly rectifying ATP-regulated potassium channel.
1993,
Pubmed
,
Xenbase
Koyama,
Molecular cloning, functional expression and localization of a novel inward rectifier potassium channel in the rat brain.
1994,
Pubmed
,
Xenbase
Krapivinsky,
The G-protein-gated atrial K+ channel IKACh is a heteromultimer of two inwardly rectifying K(+)-channel proteins.
1995,
Pubmed
,
Xenbase
Krapivinsky,
G beta gamma binds directly to the G protein-gated K+ channel, IKACh.
1995,
Pubmed
Kubo,
Primary structure and functional expression of a rat G-protein-coupled muscarinic potassium channel.
1993,
Pubmed
,
Xenbase
Kubo,
Primary structure and functional expression of a mouse inward rectifier potassium channel.
1993,
Pubmed
,
Xenbase
Kurachi,
G protein activation of cardiac muscarinic K+ channels.
1992,
Pubmed
Lesage,
Cloning provides evidence for a family of inward rectifier and G-protein coupled K+ channels in the brain.
1994,
Pubmed
,
Xenbase
Logothetis,
The beta gamma subunits of GTP-binding proteins activate the muscarinic K+ channel in heart.
,
Pubmed
Logothetis,
Specificity of action of guanine nucleotide-binding regulatory protein subunits on the cardiac muscarinic K+ channel.
1988,
Pubmed
Morishige,
Molecular cloning and functional expression of a novel brain-specific inward rectifier potassium channel.
1994,
Pubmed
,
Xenbase
Morishige,
Molecular cloning, functional expression and localization of an inward rectifier potassium channel in the mouse brain.
1993,
Pubmed
,
Xenbase
Nelson,
Cloning and characterization of Kir3.1 (GIRK1) C-terminal alternative splice variants.
1997,
Pubmed
,
Xenbase
Pfaffinger,
GTP-binding proteins couple cardiac muscarinic receptors to a K channel.
,
Pubmed
Ponce,
G-protein-gated inward rectifier K+ channel proteins (GIRK1) are present in the soma and dendrites as well as in nerve terminals of specific neurons in the brain.
1996,
Pubmed
Rudy,
Diversity and ubiquity of K channels.
1988,
Pubmed
Shuck,
Cloning and characterization of multiple forms of the human kidney ROM-K potassium channel.
1994,
Pubmed
,
Xenbase
Soejima,
Mode of regulation of the ACh-sensitive K-channel by the muscarinic receptor in rabbit atrial cells.
1984,
Pubmed
Spauschus,
A G-protein-activated inwardly rectifying K+ channel (GIRK4) from human hippocampus associates with other GIRK channels.
1996,
Pubmed
,
Xenbase