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Mol Cell Biol
2001 Aug 01;2115:5109-21. doi: 10.1128/MCB.21.15.5109-5121.2001.
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The TFIID components human TAF(II)140 and Drosophila BIP2 (TAF(II)155) are novel metazoan homologues of yeast TAF(II)47 containing a histone fold and a PHD finger.
Gangloff YG
,
Pointud JC
,
Thuault S
,
Carré L
,
Romier C
,
Muratoglu S
,
Brand M
,
Tora L
,
Couderc JL
,
Davidson I
.
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The RNA polymerase II transcription factor TFIID comprises the TATA binding protein (TBP) and a set of TBP-associated factors (TAF(II)s). TFIID has been extensively characterized for yeast, Drosophila, and humans, demonstrating a high degree of conservation of both the amino acid sequences of the constituent TAF(II)s and overall molecular organization. In recent years, it has been assumed that all the metazoan TAF(II)s have been identified, yet no metazoan homologues of yeast TAF(II)47 (yTAF(II)47) and yTAF(II)65 are known. Both of these yTAF(II)s contain a histone fold domain (HFD) which selectively heterodimerizes with that of yTAF(II)25. We have cloned a novel mouse protein, TAF(II)140, containing an HFD and a plant homeodomain (PHD) finger, which we demonstrated by immunoprecipitation to be a mammalian TFIID component. TAF(II)140 shows extensive sequence similarity to Drosophila BIP2 (dBIP2) (dTAF(II)155), which we also show to be a component of Drosophila TFIID. These proteins are metazoan homologues of yTAF(II)47 as their HFDs selectively heterodimerize with dTAF(II)24 and human TAF(II)30, metazoan homologues of yTAF(II)25. We further show that yTAF(II)65 shares two domains with the Drosophila Prodos protein, a recently described potential dTAF(II). These conserved domains are critical for yTAF(II)65 function in vivo. Our results therefore identify metazoan homologues of yTAF(II)47 and yTAF(II)65.
Aasland,
The PHD finger: implications for chromatin-mediated transcriptional regulation.
1995, Pubmed
Aasland,
The PHD finger: implications for chromatin-mediated transcriptional regulation.
1995,
Pubmed
Albright,
TAFs revisited: more data reveal new twists and confirm old ideas.
2000,
Pubmed
Bell,
Regulation of gene expression by multiple forms of TFIID and other novel TAFII-containing complexes.
1999,
Pubmed
Björses,
Mutations in the AIRE gene: effects on subcellular location and transactivation function of the autoimmune polyendocrinopathy-candidiasis-ectodermal dystrophy protein.
2000,
Pubmed
Brand,
Identification of TATA-binding protein-free TAFII-containing complex subunits suggests a role in nucleosome acetylation and signal transduction.
1999,
Pubmed
Brou,
Distinct TFIID complexes mediate the effect of different transcriptional activators.
1993,
Pubmed
Brou,
Different TBP-associated factors are required for mediating the stimulation of transcription in vitro by the acidic transactivator GAL-VP16 and the two nonacidic activation functions of the estrogen receptor.
1993,
Pubmed
Burke,
The downstream core promoter element, DPE, is conserved from Drosophila to humans and is recognized by TAFII60 of Drosophila.
1997,
Pubmed
Capili,
Solution structure of the PHD domain from the KAP-1 corepressor: structural determinants for PHD, RING and LIM zinc-binding domains.
2001,
Pubmed
Chalkley,
DNA binding site selection by RNA polymerase II TAFs: a TAF(II)250-TAF(II)150 complex recognizes the initiator.
1999,
Pubmed
Chen,
Robust mRNA transcription in chicken DT40 cells depleted of TAF(II)31 suggests both functional degeneracy and evolutionary divergence.
2000,
Pubmed
Dhalluin,
Structure and ligand of a histone acetyltransferase bromodomain.
1999,
Pubmed
Dubrovskaya,
Distinct domains of hTAFII100 are required for functional interaction with transcription factor TFIIF beta (RAP30) and incorporation into the TFIID complex.
1996,
Pubmed
Dynlacht,
Isolation of coactivators associated with the TATA-binding protein that mediate transcriptional activation.
1991,
Pubmed
Friedman,
KAP-1, a novel corepressor for the highly conserved KRAB repression domain.
1996,
Pubmed
Gangloff,
The human TFIID components TAF(II)135 and TAF(II)20 and the yeast SAGA components ADA1 and TAF(II)68 heterodimerize to form histone-like pairs.
2000,
Pubmed
Gangloff,
Histone folds mediate selective heterodimerization of yeast TAF(II)25 with TFIID components yTAF(II)47 and yTAF(II)65 and with SAGA component ySPT7.
2001,
Pubmed
Gangloff,
The histone fold is a key structural motif of transcription factor TFIID.
2001,
Pubmed
Georgieva,
Two novel Drosophila TAF(II)s have homology with human TAF(II)30 and are differentially regulated during development.
2000,
Pubmed
Gibbons,
Mutations in transcriptional regulator ATRX establish the functional significance of a PHD-like domain.
1997,
Pubmed
Godt,
Pattern formation in the limbs of Drosophila: bric à brac is expressed in both a gradient and a wave-like pattern and is required for specification and proper segmentation of the tarsus.
1993,
Pubmed
Grant,
A subset of TAF(II)s are integral components of the SAGA complex required for nucleosome acetylation and transcriptional stimulation.
1998,
Pubmed
Green,
TBP-associated factors (TAFIIs): multiple, selective transcriptional mediators in common complexes.
2000,
Pubmed
Hampsey,
Molecular genetics of the RNA polymerase II general transcriptional machinery.
1998,
Pubmed
Hernández-Hernández,
Prodos is a conserved transcriptional regulator that interacts with dTAF(II)16 in Drosophila melanogaster.
2001,
Pubmed
Jacobson,
Structure and function of a human TAFII250 double bromodomain module.
2000,
Pubmed
Jacq,
Human TAFII30 is present in a distinct TFIID complex and is required for transcriptional activation by the estrogen receptor.
1994,
Pubmed
Kokubo,
Identification of TFIID components required for transcriptional activation by upstream stimulatory factor.
1993,
Pubmed
Kokubo,
Molecular cloning, expression, and characterization of the Drosophila 85-kilodalton TFIID subunit.
1993,
Pubmed
Krämer,
Monoclonal antibody directed against RNA polymerase II of Drosophila melanogaster.
1980,
Pubmed
Le Douarin,
TIF1alpha: a possible link between KRAB zinc finger proteins and nuclear receptors.
1998,
Pubmed
Lescure,
The N-terminal domain of the human TATA-binding protein plays a role in transcription from TATA-containing RNA polymerase II and III promoters.
1994,
Pubmed
Martinez,
A human SPT3-TAFII31-GCN5-L acetylase complex distinct from transcription factor IID.
1998,
Pubmed
Matangkasombut,
Bromodomain factor 1 corresponds to a missing piece of yeast TFIID.
2000,
Pubmed
Mengus,
Human TAF(II)135 potentiates transcriptional activation by the AF-2s of the retinoic acid, vitamin D3, and thyroid hormone receptors in mammalian cells.
1997,
Pubmed
Mengus,
Cloning and characterization of hTAFII18, hTAFII20 and hTAFII28: three subunits of the human transcription factor TFIID.
1995,
Pubmed
Metzger,
Mammalian TAF(II)30 is required for cell cycle progression and specific cellular differentiation programmes.
1999,
Pubmed
Ogryzko,
Histone-like TAFs within the PCAF histone acetylase complex.
1998,
Pubmed
Pascual,
Structure of the PHD zinc finger from human Williams-Beuren syndrome transcription factor.
2000,
Pubmed
Poon,
Immunopurification of yeast TATA-binding protein and associated factors. Presence of transcription factor IIIB transcriptional activity.
1993,
Pubmed
Poot,
HuCHRAC, a human ISWI chromatin remodelling complex contains hACF1 and two novel histone-fold proteins.
2000,
Pubmed
Reese,
Identification of a yeast transcription factor IID subunit, TSG2/TAF48.
2000,
Pubmed
Saha,
The leukemia-associated-protein (LAP) domain, a cysteine-rich motif, is present in a wide range of proteins, including MLL, AF10, and MLLT6 proteins.
1995,
Pubmed
Sahut-Barnola,
Drosophila ovary morphogenesis: analysis of terminal filament formation and identification of a gene required for this process.
1995,
Pubmed
Sanders,
Identification of two novel TAF subunits of the yeast Saccharomyces cerevisiae TFIID complex.
2000,
Pubmed
Sass,
Interbands of polytene chromosomes: binding sites and start points for RNA polymerase B (II).
1982,
Pubmed
Schindler,
HAT3.1, a novel Arabidopsis homeodomain protein containing a conserved cysteine-rich region.
1993,
Pubmed
Tjian,
The biochemistry of transcription in eukaryotes: a paradigm for multisubunit regulatory complexes.
1996,
Pubmed
Verrijzer,
Drosophila TAFII150: similarity to yeast gene TSM-1 and specific binding to core promoter DNA.
1994,
Pubmed
Voss,
Taube nuss is a novel gene essential for the survival of pluripotent cells of early mouse embryos.
2000,
Pubmed
,
Xenbase
Walker,
Transcription activation in cells lacking TAFIIS.
1996,
Pubmed
Wieczorek,
Function of TAF(II)-containing complex without TBP in transcription by RNA polymerase II.
1998,
Pubmed
Xiao,
Cloning, expression, and transcriptional properties of the human enhancer factor TEF-1.
1991,
Pubmed
Zhang,
The dermatomyositis-specific autoantigen Mi2 is a component of a complex containing histone deacetylase and nucleosome remodeling activities.
1998,
Pubmed
Zhou,
Holo-TFIID supports transcriptional stimulation by diverse activators and from a TATA-less promoter.
1992,
Pubmed
Zink,
In vivo binding pattern of a trans-regulator of homoeotic genes in Drosophila melanogaster.
1989,
Pubmed
vom Baur,
Differential ligand-dependent interactions between the AF-2 activating domain of nuclear receptors and the putative transcriptional intermediary factors mSUG1 and TIF1.
1996,
Pubmed