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XB-ART-8188
Farmaco 2001 Sep 01;569:725-9. doi: 10.1016/s0014-827x(01)01125-9.
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Synthesis of new tricyclic melatoninergic ligands.

Tsotinis A , Panoussopoulou M , Sivananthan S , Sugden D .


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We report the synthesis and biological evaluation of a series of new tricyclic analogs of the hormone melatonin, which act as probes of the constraints at the hormone's receptor site with regard to the lower N1-C2 region of the indole moiety of melatonin. Three of the new compounds, N-[2-(2-methoxy-6,7,8,9-tetrahydropyrido[1,2-a]indol-10-yl)ethyl]acetamide (9), and the respective propionamide 10 and butyramide 11, are as potent as melatonin in the Xenopus laevis melanophore model.

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