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Development
2006 Feb 01;1334:697-709. doi: 10.1242/dev.02241.
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The C. elegans Myt1 ortholog is required for the proper timing of oocyte maturation.
Burrows AE
,
Sceurman BK
,
Kosinski ME
,
Richie CT
,
Sadler PL
,
Schumacher JM
,
Golden A
.
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Maturation promoting factor (MPF), a complex of cyclin-dependent kinase 1 and cyclin B, drives oocyte maturation in all animals. Mechanisms to block MPF activation in developing oocytes must exist to prevent precocious cell cycle progression prior to oocyte maturation and fertilization. This study sought to determine the developmental consequences of precociously activating MPF in oocytes prior to fertilization. Whereas depletion of Myt1 in Xenopus oocytes causes nuclear envelope breakdown in vitro, we found that depletion of the Myt1 ortholog WEE-1.3 in C. elegans hermaphrodites causes precocious oocyte maturation in vivo. Although such oocytes are ovulated, they are fertilization incompetent. We have also observed novel phenotypes in these precociously maturing oocytes, such as chromosome coalescence, aberrant meiotic spindle organization, and the expression of a meiosis II post-fertilization marker. Furthermore, co-depletion studies of CDK-1 and WEE-1.3 demonstrate that WEE-1.3 is dispensable in the absence of CDK-1, suggesting that CDK-1 is a major target of WEE-1.3 in C. elegans oocytes.
Albertson,
Segregation of holocentric chromosomes at meiosis in the nematode, Caenorhabditis elegans.
1993, Pubmed
Albertson,
Segregation of holocentric chromosomes at meiosis in the nematode, Caenorhabditis elegans.
1993,
Pubmed
Aris,
Identification and characterization of a yeast nucleolar protein that is similar to a rat liver nucleolar protein.
1988,
Pubmed
Bishop,
Phosphorylation of the carboxyl terminus of inner centromere protein (INCENP) by the Aurora B Kinase stimulates Aurora B kinase activity.
2002,
Pubmed
Bishop,
The Caenorhabditis elegans Aurora B kinase AIR-2 phosphorylates and is required for the localization of a BimC kinesin to meiotic and mitotic spindles.
2005,
Pubmed
Boxem,
The Caenorhabditis elegans gene ncc-1 encodes a cdc2-related kinase required for M phase in meiotic and mitotic cell divisions, but not for S phase.
1999,
Pubmed
Brenner,
The genetics of Caenorhabditis elegans.
1974,
Pubmed
Chan,
Chromosome cohesion is regulated by a clock gene paralogue TIM-1.
2003,
Pubmed
Chan,
Condensin restructures chromosomes in preparation for meiotic divisions.
2004,
Pubmed
Chase,
The polo-like kinase PLK-1 is required for nuclear envelope breakdown and the completion of meiosis in Caenorhabditis elegans.
2000,
Pubmed
Cheeseman,
A conserved protein network controls assembly of the outer kinetochore and its ability to sustain tension.
2004,
Pubmed
Colaiácovo,
A targeted RNAi screen for genes involved in chromosome morphogenesis and nuclear organization in the Caenorhabditis elegans germline.
2002,
Pubmed
Coleman,
Cdc2 regulatory factors.
1994,
Pubmed
Couteau,
A heterochromatin protein 1 homologue in Caenorhabditis elegans acts in germline and vulval development.
2002,
Pubmed
Davis,
Multiple subunits of the Caenorhabditis elegans anaphase-promoting complex are required for chromosome segregation during meiosis I.
2002,
Pubmed
Dernburg,
Meiotic recombination in C. elegans initiates by a conserved mechanism and is dispensable for homologous chromosome synapsis.
1998,
Pubmed
Detwiler,
Two zinc finger proteins, OMA-1 and OMA-2, are redundantly required for oocyte maturation in C. elegans.
2001,
Pubmed
Dorée,
From Cdc2 to Cdk1: when did the cell cycle kinase join its cyclin partner?
2002,
Pubmed
Edgar,
Blastomere culture and analysis.
1995,
Pubmed
Fire,
Potent and specific genetic interference by double-stranded RNA in Caenorhabditis elegans.
1998,
Pubmed
Fischle,
Regulation of HP1-chromatin binding by histone H3 methylation and phosphorylation.
2005,
Pubmed
,
Xenbase
Furuta,
EMB-30: an APC4 homologue required for metaphase-to-anaphase transitions during meiosis and mitosis in Caenorhabditis elegans.
2000,
Pubmed
Golden,
Metaphase to anaphase (mat) transition-defective mutants in Caenorhabditis elegans.
2000,
Pubmed
Gönczy,
Functional genomic analysis of cell division in C. elegans using RNAi of genes on chromosome III.
2000,
Pubmed
Hagstrom,
C. elegans condensin promotes mitotic chromosome architecture, centromere organization, and sister chromatid segregation during mitosis and meiosis.
2002,
Pubmed
,
Xenbase
Han,
Wee1B is an oocyte-specific kinase involved in the control of meiotic arrest in the mouse.
2005,
Pubmed
,
Xenbase
Hanazawa,
Use of cDNA subtraction and RNA interference screens in combination reveals genes required for germ-line development in Caenorhabditis elegans.
2001,
Pubmed
Hendzel,
Mitosis-specific phosphorylation of histone H3 initiates primarily within pericentromeric heterochromatin during G2 and spreads in an ordered fashion coincident with mitotic chromosome condensation.
1997,
Pubmed
Henríquez,
Isolation and sequencing of NOP1. A yeast gene encoding a nucleolar protein homologous to a human autoimmune antigen.
1990,
Pubmed
Hsu,
Mitotic phosphorylation of histone H3 is governed by Ipl1/aurora kinase and Glc7/PP1 phosphatase in budding yeast and nematodes.
2000,
Pubmed
Iwasaki,
emo-1, a Caenorhabditis elegans Sec61p gamma homologue, is required for oocyte development and ovulation.
1996,
Pubmed
Kamath,
Systematic functional analysis of the Caenorhabditis elegans genome using RNAi.
2003,
Pubmed
Lamitina,
Dominant mutations in the Caenorhabditis elegans Myt1 ortholog wee-1.3 reveal a novel domain that controls M-phase entry during spermatogenesis.
2002,
Pubmed
MacQueen,
Nuclear reorganization and homologous chromosome pairing during meiotic prophase require C. elegans chk-2.
2001,
Pubmed
Maeda,
Large-scale analysis of gene function in Caenorhabditis elegans by high-throughput RNAi.
2001,
Pubmed
McCarter,
On the control of oocyte meiotic maturation and ovulation in Caenorhabditis elegans.
1999,
Pubmed
McDowall,
Genetic analysis of sterile mutants in the dpy-5 unc-13 (I) genomic region of Caenorhabditis elegans.
1997,
Pubmed
Miller,
A sperm cytoskeletal protein that signals oocyte meiotic maturation and ovulation.
2001,
Pubmed
Miller,
An Eph receptor sperm-sensing control mechanism for oocyte meiotic maturation in Caenorhabditis elegans.
2003,
Pubmed
Mito,
Distinct developmental function of two Caenorhabditis elegans homologs of the cohesin subunit Scc1/Rad21.
2003,
Pubmed
Nabeshima,
Crossing over is coupled to late meiotic prophase bivalent differentiation through asymmetric disassembly of the SC.
2005,
Pubmed
Nakajo,
Absence of Wee1 ensures the meiotic cell cycle in Xenopus oocytes.
2000,
Pubmed
,
Xenbase
Nieduszynski,
Whole-genome analysis of animal A- and B-type cyclins.
2002,
Pubmed
Oegema,
Functional analysis of kinetochore assembly in Caenorhabditis elegans.
2001,
Pubmed
Page,
The C. elegans E2F- and DP-related proteins are required for embryonic asymmetry and negatively regulate Ras/MAPK signaling.
2001,
Pubmed
Pasierbek,
A Caenorhabditis elegans cohesion protein with functions in meiotic chromosome pairing and disjunction.
2001,
Pubmed
Pellettieri,
Coordinate activation of maternal protein degradation during the egg-to-embryo transition in C. elegans.
2003,
Pubmed
Piano,
RNAi analysis of genes expressed in the ovary of Caenorhabditis elegans.
,
Pubmed
Powers,
Loss of KLP-19 polar ejection force causes misorientation and missegregation of holocentric chromosomes.
2004,
Pubmed
Praitis,
Creation of low-copy integrated transgenic lines in Caenorhabditis elegans.
2001,
Pubmed
Quintin,
The mbk-2 kinase is required for inactivation of MEI-1/katanin in the one-cell Caenorhabditis elegans embryo.
2003,
Pubmed
Reboul,
C. elegans ORFeome version 1.1: experimental verification of the genome annotation and resource for proteome-scale protein expression.
2003,
Pubmed
Riddle,
Developmental Genetics of the Germ Line
1997,
Pubmed
Schimmang,
A yeast nucleolar protein related to mammalian fibrillarin is associated with small nucleolar RNA and is essential for viability.
1989,
Pubmed
Schmitt,
Signalling pathways in oocyte meiotic maturation.
2002,
Pubmed
,
Xenbase
Schumacher,
AIR-2: An Aurora/Ipl1-related protein kinase associated with chromosomes and midbody microtubules is required for polar body extrusion and cytokinesis in Caenorhabditis elegans embryos.
1998,
Pubmed
Segbert,
KLP-18, a Klp2 kinesin, is required for assembly of acentrosomal meiotic spindles in Caenorhabditis elegans.
2003,
Pubmed
Simmer,
Genome-wide RNAi of C. elegans using the hypersensitive rrf-3 strain reveals novel gene functions.
2003,
Pubmed
Stitzel,
The C. elegans DYRK Kinase MBK-2 Marks Oocyte Proteins for Degradation in Response to Meiotic Maturation.
2006,
Pubmed
Stumpff,
Drosophila Wee1 interacts with members of the gammaTURC and is required for proper mitotic-spindle morphogenesis and positioning.
2005,
Pubmed
Sulston,
Post-embryonic cell lineages of the nematode, Caenorhabditis elegans.
1977,
Pubmed
Varmark,
Functional role of centrosomes in spindle assembly and organization.
2004,
Pubmed
Voronina,
The regulation of oocyte maturation.
2003,
Pubmed
Wallenfang,
Polarization of the anterior-posterior axis of C. elegans is a microtubule-directed process.
2000,
Pubmed
Wang,
RNA interference in Caenorhabditis elegans.
2005,
Pubmed
Wilson,
A Caenorhabditis elegans wee1 homolog is expressed in a temporally and spatially restricted pattern during embryonic development.
1999,
Pubmed
Yang,
MEI-1/katanin is required for translocation of the meiosis I spindle to the oocyte cortex in C elegans.
2003,
Pubmed
