XB-ART-7909
Neurosci Lett
2002 Jan 11;3172:77-80. doi: 10.1016/s0304-3940(01)02430-2.
Show Gene links
Show Anatomy links
Specificity of putative partial agonist, 1-aminocyclopropanecarboxylic acid, for rat N-methyl-D-aspartate receptor subunits.
???displayArticle.abstract???
The neuroprotective compound, 1-aminocyclopropanecarboxylic acid (ACPC), has been reported to act on the N-methyl-D-aspartate (NMDA) receptors simultaneously as a glycine binding site agonist and a glutamate binding site competitive antagonist. The complex kinetics of NMDA current changes measured by a whole-cell voltage clamp in rat hippocampal neurons resulting from application and removal of 1 mM ACPC in the continual presence of 15 microM NMDA confirm this hypothesis. Two-electrode voltage clamp on Xenopus oocytes expressing NR1-1a and either NR2A, NR2B or NR2C subunits yielded biphasic ACPC dose response curves with 15 microM NMDA. NR1-1a/NR2B and NR1-1a/NR2C subunit combinations yielded overlapping dose response curves with a maximal efficacy of approximately 80%; the maximal efficacy of ACPC for the NR1-1a/NR2A subunit combination was significantly lower at approximately 60%.
???displayArticle.pubmedLink??? 11755244
???displayArticle.link??? Neurosci Lett
Species referenced: Xenopus laevis
Genes referenced: grin1 grin2a grin2b grin2c