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XB-ART-7622
Oncogene 2002 Feb 14;218:1150-8. doi: 10.1038/sj.onc.1205175.
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Oncogenic potential of the DNA replication licensing protein CDT1.

Arentson E , Faloon P , Seo J , Moon E , Studts JM , Fremont DH , Choi K .


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The expression of a gene, designated as Retroviral insertion site (Ris)2, was activated by retroviral DNA integration in an immortalized primitive erythroid cell line, EB-PE. Ris2 was also expressed at high levels in all human tumor cell lines analysed. Consistently, NIH3T3 fibroblasts overexpressing Ris2 formed tumors in Rag2 -/- mice when injected subcutaneously. The putative RIS2 protein shows a high sequence similarity to Xenopus CDT1, Drosophila DUP, and human CDT1, a newly identified DNA replication licensing protein, suggesting that Ris2 is a mouse homologue of CDT1. Cells overexpressing Ris2/Cdt1 exhibited a quicker entry into S phase when released from serum starvation compared to controls. Our results suggest that CDT1, an essential licensing protein for DNA replication, can function as an oncogene in mammals.

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Species referenced: Xenopus
Genes referenced: cdt1 rag2